Closo-decahydrodecaborateanion,[B10H10]2, is one of the most notable clusters in the familyof hydroborates, partly attributed to its unique electronic structureandits thermal and chemical stability. The major challenge in the development of [B10H10]2 chemistry resides in its functionalization via the activation o fexo-polyhedralBH bonds to BL bonds to generate attractive molecular construction modules or ‘archetypes’ of useful applications. To date, the closo-[B10H10]2 cage has been functionalized with a wide range of functional groups-L such as halogens, amines, thiols, alkoxy, hydroxyl and multifunctional moieties to yield mono-or poly-substituted borate derivatives.In this review, we present the recent trends in the chemistryof closo-decaborate with focus on the substitution reactions of hydrogenatoms by various entities