Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad - Archive ouverte HAL Access content directly
Journal Articles Science Advances Year : 2022

Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad

Aitana Perea-Gomez
Corey Bunce
Pam Siggers
Ivana Gantar
Furong Tang
Laura Batti
Dagmar Wilhelm
Andy Greenfield
Blanche Capel

Abstract

Gonadal sex determination represents a unique model for studying cell fate decisions. However, a complete understanding of the different cell lineages forming the developing testis and ovary remains elusive. Here, we investigated the origin, specification, and subsequent sex-specific differentiation of a previously uncharacterized population of supporting-like cells (SLCs) in the developing mouse gonads. The SLC lineage is closely related to the coelomic epithelium and specified as early as E10.5, making it the first somatic lineage to be specified in the bipotential gonad. SLC progenitors are localized within the genital ridge at the interface with the mesonephros and initially coexpress Wnt4 and Sox9 . SLCs become sexually dimorphic around E12.5, progressively acquire a more Sertoli- or pregranulosa-like identity and contribute to the formation of the rete testis and rete ovarii. Last, we found that WNT4 is a crucial regulator of the SLC lineage and is required for normal development of the rete testis.
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hal-03684448 , version 1 (01-06-2022)

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Chloé Mayère, Violaine Regard, Aitana Perea-Gomez, Corey Bunce, Yasmine Neirijnck, et al.. Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad. Science Advances , 2022, 8 (21), ⟨10.1126/sciadv.abm0972⟩. ⟨hal-03684448⟩
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