Prevalence of sexual dimorphism in mammalian phenotypic traits
Natasha Karp
(1, 2)
,
Jeremy Mason
(3)
,
Arthur Beaudet
(4)
,
Yoav Benjamini
(5)
,
Lynette Bower
(6)
,
Robert Braun
(7)
,
Steve Brown
(8)
,
Elissa Chesler
(7)
,
Mary Dickinson
(4)
,
Ann Flenniken
,
Helmut Fuchs
(9)
,
Martin Hrabe de Angelis
(9, 10, 11)
,
Xiang Gao
(12)
,
Shiying Guo
(12)
,
Simon Greenaway
(8)
,
Ruth Heller
(5)
,
Yann Herault
(13, 14, 15)
,
Monica Justice
(16)
,
Natalja Kurbatova
(5)
,
Christopher Lelliott
(1)
,
K Lloyd
(6)
,
Ann-Marie Mallon
(8)
,
Judith Mank
(17)
,
Hiroshi Masuya
(18)
,
Colin Mckerlie
(16)
,
Terrence Meehan
(3)
,
Richard Mott
(17)
,
Stephen Murray
(7)
,
Helen Parkinson
(3)
,
Ramiro Ramirez-Solis
(1)
,
Luis Santos
(8)
,
John Seavitt
(4)
,
Damian Smedley
(19)
,
Tania Sorg-Guss
(13, 14, 15)
,
Anneliese Speak
(1)
,
Karen Steel
(1, 20)
,
Karen Svenson
(7)
,
Shigeharu Wakana
(18)
,
David West
(21)
,
Sara Wells
(8)
,
Henrik Westerberg
(8)
,
Shay Yaacoby
(5)
,
Jacqueline White
(7, 1)
1
The Wellcome Trust Sanger Institute [Cambridge]
2 AstraZeneca [Cambridge, UK]
3 EMBL-EBI - European Bioinformatics Institute [Hinxton]
4 BCM - Baylor College of Medicine
5 TAU - Tel Aviv University
6 UC Davis - University of California [Davis]
7 JAX - The Jackson Laboratory [Bar Harbor]
8 MRC Harwell Institute [UK]
9 HMGU - Helmholtz Zentrum München = German Research Center for Environmental Health
10 TUM - Technische Universität Munchen - Technical University Munich - Université Technique de Munich
11 DZD - German Center for Diabetes Research - Deutsches Zentrum für Diabetesforschung [Neuherberg]
12 NJU - Nanjing University
13 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire
14 PHENOMIN - French National Infrastructure for Mouse Phenogenomics
15 ICS - Institut Clinique de la Souris
16 SickKids - The Hospital for sick children [Toronto]
17 UCL - University College of London [London]
18 RIKEN BRC - RIKEN BioResource Research Center [Tsukuba, Japan]
19 QMUL - Queen Mary University of London
20 King‘s College London
21 Children's Hospital Oakland Research Institute (CHORI)
2 AstraZeneca [Cambridge, UK]
3 EMBL-EBI - European Bioinformatics Institute [Hinxton]
4 BCM - Baylor College of Medicine
5 TAU - Tel Aviv University
6 UC Davis - University of California [Davis]
7 JAX - The Jackson Laboratory [Bar Harbor]
8 MRC Harwell Institute [UK]
9 HMGU - Helmholtz Zentrum München = German Research Center for Environmental Health
10 TUM - Technische Universität Munchen - Technical University Munich - Université Technique de Munich
11 DZD - German Center for Diabetes Research - Deutsches Zentrum für Diabetesforschung [Neuherberg]
12 NJU - Nanjing University
13 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire
14 PHENOMIN - French National Infrastructure for Mouse Phenogenomics
15 ICS - Institut Clinique de la Souris
16 SickKids - The Hospital for sick children [Toronto]
17 UCL - University College of London [London]
18 RIKEN BRC - RIKEN BioResource Research Center [Tsukuba, Japan]
19 QMUL - Queen Mary University of London
20 King‘s College London
21 Children's Hospital Oakland Research Institute (CHORI)
Jeremy Mason
- Fonction : Auteur
- PersonId : 765082
- ORCID : 0000-0002-2796-5123
Robert Braun
- Fonction : Auteur
- PersonId : 797885
- ORCID : 0000-0003-3856-9465
Steve Brown
- Fonction : Auteur
- PersonId : 797886
- ORCID : 0000-0002-0617-4824
Ann Flenniken
- Fonction : Auteur
- PersonId : 797880
- ORCID : 0000-0003-1892-6154
Martin Hrabe de Angelis
- Fonction : Auteur
- PersonId : 758367
- ORCID : 0000-0002-7898-2353
- IdRef : 115604332
Yann Herault
- Fonction : Auteur
- PersonId : 741744
- IdHAL : yann-herault
- ORCID : 0000-0001-7049-6900
- IdRef : 077172639
Christopher Lelliott
- Fonction : Auteur
- PersonId : 804743
- ORCID : 0000-0001-8087-4530
Colin Mckerlie
- Fonction : Auteur
- PersonId : 797879
- ORCID : 0000-0002-2232-0967
Richard Mott
- Fonction : Auteur
- PersonId : 770151
- ORCID : 0000-0002-1022-9330
John Seavitt
- Fonction : Auteur
- PersonId : 797882
- ORCID : 0000-0003-3209-3187
Karen Svenson
- Fonction : Auteur
- PersonId : 797884
- ORCID : 0000-0002-7928-1911
Sara Wells
- Fonction : Auteur
- PersonId : 764221
- ORCID : 0000-0002-0572-0600
Jacqueline White
- Fonction : Auteur
- PersonId : 804735
- ORCID : 0000-0001-6268-2826
Résumé
The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.
Domaines
GénétiqueOrigine | Fichiers éditeurs autorisés sur une archive ouverte |
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