Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills
Doretta Caramaschi
(1, 2)
,
Alexander Neumann
(3, 4)
,
Andres Cardenas
(5)
,
Gwen Tindula
(5)
,
Silvia Alemany
(6, 7)
,
Lea Zillich
(8)
,
Giancarlo Pesce
(9)
,
Jari Lahti
(10)
,
Alexandra Havdahl
(11, 1)
,
Rosa Mulder
(3)
,
Janine Felix
(3)
,
Henning Tiemeier
(3)
,
Lea Sirignano
(8)
,
Josef Frank
(8)
,
Stephanie Witt
(8)
,
Marcella Rietschel
(8)
,
Michael Deuschle
(12)
,
Karen Huen
(13)
,
Brenda Eskenazi
(5)
,
Tabea Sarah Send
(12)
,
Muriel Ferrer
(6)
,
Maria Gilles
(12)
,
Maria de Agostini
(14)
,
Nour Baïz
(15)
,
Sheryl Rifas-Shiman
(16)
,
Tuomas Kvist
(10)
,
Darina Czamara
(17)
,
Samuli Tuominen
(10)
,
Caroline Relton
(1)
,
Dheeraj Rai
(1)
,
Stephanie London
,
Katri Räikkönen
(10)
,
Nina Holland
(18)
,
Isabella Annesi‐maesano
(9, 19)
,
Fabian Streit
(12)
,
Marie-France Hivert
(16)
,
Emily Oken
(16)
,
Jordi Sunyer
(6, 7, 20)
,
Charlotte Cecil
(3, 21)
,
Gemma Sharp
(1)
1
University of Bristol [Bristol]
2 University of Exeter
3 Erasmus MC - Erasmus University Medical Center [Rotterdam]
4 Montreal General Hospital
5 School of Public Health [Berkeley]
6 ISGlobal - Instituto de Salud Global - Institute For Global Health [Barcelona]
7 UPF - Universitat Pompeu Fabra [Barcelona]
8 University of Heidelberg, Medical Faculty
9 EPAR - Epidemiology of Allergic and Respiratory Diseases Department [iPlesp]
10 Helsingin yliopisto = Helsingfors universitet = University of Helsinki
11 NIPH - Norwegian Institute of Public Health [Oslo]
12 University Hospital Mannheim | Universitätsmedizin Mannheim
13 UC Berkeley - University of California [Berkeley]
14 CRESS (U1153 / UMR_A 1125) - Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques
15 SU FM - Sorbonne Université - Faculté de Médecine
16 HMS - Harvard Medical School [Boston]
17 Max Planck Institute of Psychiatry
18 UC - University of California
19 IDESP - Institut Desbrest de santé publique
20 CIBERESP - CIBER Epidemiologia y Salud Pùblica [Madrid, Spain]
21 LUMC - Leiden University Medical Center
2 University of Exeter
3 Erasmus MC - Erasmus University Medical Center [Rotterdam]
4 Montreal General Hospital
5 School of Public Health [Berkeley]
6 ISGlobal - Instituto de Salud Global - Institute For Global Health [Barcelona]
7 UPF - Universitat Pompeu Fabra [Barcelona]
8 University of Heidelberg, Medical Faculty
9 EPAR - Epidemiology of Allergic and Respiratory Diseases Department [iPlesp]
10 Helsingin yliopisto = Helsingfors universitet = University of Helsinki
11 NIPH - Norwegian Institute of Public Health [Oslo]
12 University Hospital Mannheim | Universitätsmedizin Mannheim
13 UC Berkeley - University of California [Berkeley]
14 CRESS (U1153 / UMR_A 1125) - Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques
15 SU FM - Sorbonne Université - Faculté de Médecine
16 HMS - Harvard Medical School [Boston]
17 Max Planck Institute of Psychiatry
18 UC - University of California
19 IDESP - Institut Desbrest de santé publique
20 CIBERESP - CIBER Epidemiologia y Salud Pùblica [Madrid, Spain]
21 LUMC - Leiden University Medical Center
Doretta Caramaschi
- Fonction : Auteur
- PersonId : 827310
- ORCID : 0000-0002-9740-871X
Andres Cardenas
- Fonction : Auteur
- PersonId : 820938
- ORCID : 0000-0003-2284-3298
Silvia Alemany
- Fonction : Auteur
- PersonId : 818637
- ORCID : 0000-0002-7925-6767
Giancarlo Pesce
- Fonction : Auteur
- PersonId : 799205
- ORCID : 0000-0003-4925-6325
Jari Lahti
- Fonction : Auteur
- PersonId : 775392
- ORCID : 0000-0002-4310-5297
Alexandra Havdahl
- Fonction : Auteur
- PersonId : 809756
- ORCID : 0000-0002-9268-0423
Janine Felix
- Fonction : Auteur
- PersonId : 801129
- ORCID : 0000-0002-9801-5774
Henning Tiemeier
- Fonction : Auteur
- PersonId : 763597
- ORCID : 0000-0002-4395-1397
Lea Sirignano
- Fonction : Auteur
- PersonId : 818809
- ORCID : 0000-0002-7989-5833
Josef Frank
- Fonction : Auteur
- PersonId : 769356
- ORCID : 0000-0003-4867-9465
Stephanie Witt
- Fonction : Auteur
- PersonId : 804383
- ORCID : 0000-0002-1571-1468
Marcella Rietschel
- Fonction : Auteur
- PersonId : 757743
- ORCID : 0000-0002-5236-6149
Darina Czamara
- Fonction : Auteur
- PersonId : 764411
- ORCID : 0000-0001-7381-904X
Samuli Tuominen
- Fonction : Auteur
- PersonId : 806401
- ORCID : 0000-0002-1879-0739
Stephanie London
- Fonction : Auteur
- PersonId : 759648
- ORCID : 0000-0003-4911-5290
Isabella Annesi‐maesano
- Fonction : Auteur
- PersonId : 754596
- IdHAL : isabella-annesi-maesano
- ORCID : 0000-0002-6340-9300
- IdRef : 123241847
Fabian Streit
- Fonction : Auteur
- PersonId : 792531
- ORCID : 0000-0003-1080-4339
Marie-France Hivert
- Fonction : Auteur
- PersonId : 773567
- ORCID : 0000-0001-7752-2585
Gemma Sharp
- Fonction : Auteur
- PersonId : 799479
- ORCID : 0000-0003-2906-4035
Résumé
Abstract Cognitive skills are a strong predictor of a wide range of later life outcomes. Genetic and epigenetic associations across the genome explain some of the variation in general cognitive abilities in the general population and it is plausible that epigenetic associations might arise from prenatal environmental exposures and/or genetic variation early in life. We investigated the association between cord blood DNA methylation at birth and cognitive skills assessed in children from eight pregnancy cohorts within the Pregnancy And Childhood Epigenetics (PACE) Consortium across overall (total N = 2196), verbal (total N = 2206) and non-verbal cognitive scores (total N = 3300). The associations at single CpG sites were weak for all of the cognitive domains investigated. One region near DUSP22 on chromosome 6 was associated with non-verbal cognition in a model adjusted for maternal IQ. We conclude that there is little evidence to support the idea that variation in cord blood DNA methylation at single CpG sites is associated with cognitive skills and further studies are needed to confirm the association at DUSP22 .
Domaines
Sciences du Vivant [q-bio]
Origine : Publication financée par une institution