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Article Dans Une Revue Chemical Communications Année : 2018

Minimising conformational bias in fluoroprolines through vicinal difluorination

Résumé

Monofluorination at the proline 4-position results in conformational effects, which is exploited for a range of applications. However, this conformational distortion is a hindrance when the natural proline conformation is important. Here we introduce (3S,4R)-3,4-difluoroproline, in which the individual fluorine atoms instil opposite conformational effects, as a suitable probe for fluorine NMR studies.

Domaines

Chimie organique
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Origine : Publication financée par une institution

Dates et versions

hal-03671903 , version 1 (18-05-2022)

Identifiants

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Gert-Jan Hofman, Emile Ottoy, Mark Light, Bruno Kieffer, Ilya Kuprov, et al.. Minimising conformational bias in fluoroprolines through vicinal difluorination. Chemical Communications, 2018, 54 (40), pp.5118-5121. ⟨10.1039/c8cc01493k⟩. ⟨hal-03671903⟩
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