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Journal Articles European Journal of Immunology Year : 2018

Med1 deficiency alters the somatic hypermutation spectrum in murine B cells

Abstract

The Mediator complex is known to orchestrate transcription. Here we show that B cell conditional deficient mice for the Med1 subunit display robust somatic hypermutation. Nevertheless, the mutation frequency at A residues is decreased and the expected A/T ratio is abolished, implicating Mediator in the second phase of somatic hypermutation.

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Immunology

Dates and versions

hal-03671896 , version 1 (18-05-2022)

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Léa Gaudot, Anne-Sophie Thomas-Claudepierre, Isabelle Robert, Ebe Schiavo, Vincent Heyer, et al.. Med1 deficiency alters the somatic hypermutation spectrum in murine B cells. European Journal of Immunology, 2018, 48 (4), pp.720-723. ⟨10.1002/eji.201747258⟩. ⟨hal-03671896⟩
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