Retinol-binding protein 2 (RBP2) binds monoacylglycerols and modulates gut endocrine signaling and body weight - Archive ouverte HAL Access content directly
Journal Articles Science Advances Year : 2020

Retinol-binding protein 2 (RBP2) binds monoacylglycerols and modulates gut endocrine signaling and body weight

Abstract

Expressed in the small intestine, retinol-binding protein 2 (RBP2) facilitates dietary retinoid absorption. Rbp2-deficient (Rbp2(-/-) ) mice fed a chow diet exhibit by 6-7 months-of-age higher body weights, impaired glucose metabolism, and greater hepatic triglyceride levels compared to controls. These phenotypes are also observed when young Rbp2(-/-) mice are fed a high fat diet. Retinoids do not account for the phenotypes. Rather, RBP2 is a previously unidentified monoacylglycerol (MAG)-binding protein, interacting with the endocannabinoid 2-arachidonoylglycerol (2-AG) and other MAGs with affinities comparable to retinol. X-ray crystallographic studies show that MAGs bind in the retinol binding pocket. When challenged with an oil gavage, Rbp2(-/-) mice show elevated mucosal levels of 2-MAGs. This is accompanied by significantly elevated blood levels of the gut hormone GIP (glucose-dependent insulinotropic polypeptide). Thus, RBP2, in addition to facilitating dietary retinoid absorption, modulates MAG metabolism and likely signaling, playing a heretofore unknown role in systemic energy balance.
Fichier principal
Vignette du fichier
islandora_151082.pdf (1.86 Mo) Télécharger le fichier
Origin Publisher files allowed on an open archive

Dates and versions

hal-03669753 , version 1 (16-05-2022)

Identifiers

Cite

Sueng-Ah Lee, Kryscilla Yang, Pierre-Jacques Brun, Josie Silvaroli, Jason Yuen, et al.. Retinol-binding protein 2 (RBP2) binds monoacylglycerols and modulates gut endocrine signaling and body weight. Science Advances , 2020, 6 (11), pp.32195347. ⟨10.1126/sciadv.aay8937⟩. ⟨hal-03669753⟩
29 View
26 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More