This work aims to understand the modulation of turbulence by particles under controlled macroscopic shear stress and bulk Reynolds number (plane Couette flow). We perform resolved two phase flow simulations with the aid of the Force-Coupling Method. The minimum flow unit is used (Hamilton et al.JFM 1995), with different ratios of Couette gap width to particle diameter, Reynolds numbers and concentrations. Results on the particle distribution, their interaction with the large scale structures, and the induced modification of the flow turbulence properties will be analyzed and discussed.