The potential impact of salivary peptides in periodontitis - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Critical Reviews in Clinical Laboratory Sciences Année : 2021

The potential impact of salivary peptides in periodontitis

Résumé

Periodontitis is a complex immune-inflammatory condition characterized by the disruption of the periodontal ligament and subsequent formation of periodontal pockets, and by alveolar bone loss, often resulting in tooth loss. A myriad of factors, namely, genetic, metabolic, immunological, and inflammatory, is associated with progression of periodontitis. Periodontitis is also associated with systemic conditions such as neoplastic disorders, obesity, and diabetes. The current diagnosis of this disease relies on clinical measurements such as clinical attachment loss and probing depth, which have poor precision due to patient, operator and probe-related factors. Thus, there is a need to develop reliable, objective, and reproducible biomarkers for early diagnosis of periodontitis. In this regard, saliva, with contributions from the gingival crevicular fluid, holds great potential. However, most of the information on biomarkers of periodontium-related salivary proteins has come from studies on the molecular pathogenesis of periodontitis. In periodontitis, a more holistic approach, such as the use of -omics technologies, for biomarker discovery, is needed. Herein, we review the biomarkers proposed to date for the assessment of periodontitis, with emphasis on the role of salivary peptides in periodontitis and their assessment by high-throughput saliva proteomics. We also discuss the challenges pertaining to the identification of new periodontitis biomarkers in saliva.
Fichier non déposé

Dates et versions

hal-03659724 , version 1 (05-05-2022)

Identifiants

Citer

Christophe Hirtz, Robin O'Flynn, Pierre Marie Voisin, Dominique Deville de Périère, Sylvain Lehmann, et al.. The potential impact of salivary peptides in periodontitis. Critical Reviews in Clinical Laboratory Sciences, 2021, 58 (7), pp.479-492. ⟨10.1080/10408363.2021.1907298⟩. ⟨hal-03659724⟩
19 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More