Palladium-Catalyzed Oxidative sp 2 C−H Bond Acylation with Alcohols
Résumé
An efficient method was developed for the direct acylation of arene sp2 C−H bonds with alcohols using palladium chloride as a catalyst and peroxide as the oxidant. The alcohols were oxidized to their corresponding aldehydes in situ and efficiently coupled with 2-arylpyridines to give aryl ketones in chlorobenzene.