Refined assessments of the available tidal stream energy resource are required to optimize turbines design and guarantee successful implementations and operations of devices in the marine environment. Investigations primary focused on identifying areas with maximum current speeds. However, further information may be reached by exhibiting (i) resource temporal variability, (ii) superimposed effects of meteo-oceanographic conditions (including especially wind-generated surface-gravity waves), and (iii) potential environmental impacts of operating turbines at the regional (e.g., changes in sediment transport and surrounding seabed features, effects on marine water quality, etc.) and local (wake-wake interactions and energy output) scales. These aspects are here investigated by reviewing a series of research studies dedicated to the Fromveur Strait off western Brittany, a region with strong potential for tidal array development along the coast of France. Particular attention is dedicated to the exploitation of combined in-situ and remote-sensing observations and numerical simulations. Beyond a site specific characterization of the tidal stream energy resource, this review promotes a series of original approaches and analysis methods for turbines optimization, thus complementing technical specifications to secure the key steps of a tidal energy project and promote the growth of a reliable tidal stream energy exploitation.