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Article Dans Une Revue Genes, Chromosomes & Cancer Année : 1998

Chromosome region 8p11-p21: Refined mapping and molecular alterations in breast cancer

José Adélaïde
  • Fonction : Auteur
Alexandra Imbert
  • Fonction : Auteur
Florence Allione
  • Fonction : Auteur
Jeanine Geneix
  • Fonction : Auteur
Cornel Popovici
Dirk van Alewijk
  • Fonction : Auteur
Jan Trapman
  • Fonction : Auteur
Robert Zeillinger
  • Fonction : Auteur
Anne-Lise Børresen-Dale
  • Fonction : Auteur
Rosette Lidereau
  • Fonction : Auteur
Daniel Birnbaum
Marie-Josèphe Pébusque
  • Fonction : Auteur

Résumé

Several genes, most of them unknown, of the short arm of chromosome 8 are involved in malignant diseases. Numerous studies have implicated a portion of the 8p11-p21 region as the location of one or more tumor suppressor genes involved in a variety of human cancers, including breast cancer. We and others have reported linkage analyses suggesting the presence of a putative breast cancer susceptibility gene. Furthermore, several oncogenes of the 8p11-p12 region are involved in reciprocal translocations in myeloproliferative and myelodysplastic disorders and in amplification in breast cancer. To facilitate the analysis of the 8p11-p21 region and the cloning of candidate oncogenes and tumor suppressor genes, a high-resolution physical and transcriptional map was established with 39 yeast artificial chromosomes and 94 markers, including so-called sequence-tagged sites and expressed sequence-tagged sites derived from either known genes or expressed sequence tags corresponding to unidentified transcripts. In addition, four novel transcripts were identified and localized precisely within the map. This transcription map provides a detailed description of gene order for the 8p11-p21 region and will be helpful in the identification of candidate genes for diseases. From this basis, we refined the mapping of two types of molecular alterations that occur at 8p11-p21 in sporadic breast cancers, i.e., amplification and deletion.

Domaines

Cancer

Dates et versions

hal-03634451 , version 1 (07-04-2022)

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Citer

José Adélaïde, Max Chaffanet, Alexandra Imbert, Florence Allione, Jeanine Geneix, et al.. Chromosome region 8p11-p21: Refined mapping and molecular alterations in breast cancer. Genes, Chromosomes & Cancer, 1998, 22 (3), pp.186-199. ⟨10.1002/(SICI)1098-2264(199807)22:3<186::AID-GCC4>3.0.CO;2-S⟩. ⟨hal-03634451⟩

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