A case of inv(8)(p11q24) associated with acute myeloid leukemia involves theMOZ andCBP genes in a masked t(8;16) - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Genes, Chromosomes & Cancer Année : 1999

A case of inv(8)(p11q24) associated with acute myeloid leukemia involves theMOZ andCBP genes in a masked t(8;16)

Marie-Joëlle Mozziconacci
  • Fonction : Auteur
Francisca Fernandez
  • Fonction : Auteur
Danielle Sainty
  • Fonction : Auteur
Marina Lafage-Pochitaloff
  • Fonction : Auteur
Daniel Birnbaum
Marie-Josèphe Pébusque
  • Fonction : Auteur

Résumé

We report on a novel chromosomal aberration, inv(8)(p11q24), in an M5 acute myeloid leukemia. We show by fluorescence in situ hybridization and Southern blot analyses that a t(8;16)(p11;p13) is masked by this inversion. The translocation targets the MOZ gene from the 8p11 and the CBP gene from the 16p13 chromosomal regions. The breakpoints occur in the MOZ region encoding the acidic domain and in the 5' end of the CBP gene. These results provide further evidence for the multiple contribution of both MOZ and CBP genes in acute leukemias.

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Cancer
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Dates et versions

hal-03634445 , version 1 (07-04-2022)

Identifiants

  • HAL Id : hal-03634445 , version 1
  • PUBMED : 10469454

Citer

Max Chaffanet, Marie-Joëlle Mozziconacci, Francisca Fernandez, Danielle Sainty, Marina Lafage-Pochitaloff, et al.. A case of inv(8)(p11q24) associated with acute myeloid leukemia involves theMOZ andCBP genes in a masked t(8;16). Genes, Chromosomes & Cancer, 1999, 26 (2), pp.161-165. ⟨hal-03634445⟩

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