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Article Dans Une Revue Natural Product Reports Année : 2012

The nonribosomal synthesis of diketopiperazines in tRNA-dependent cyclodipeptide synthase pathways

Résumé

We review here work on the biosynthesis of diketopiperazines (DKPs), a large class of natural products with noteworthy biological activities, focusing on the biosynthetic pathways involving cyclodipeptide synthases (CDPSs), a newly defined family of enzymes. Distinct from nonribosomal peptide synthetases (NRPSs), the other family of enzymes synthesizing DKPs, CDPSs bridge the primary and secondary metabolic pathways by hijacking aminoacyl-tRNAs to produce DKPs. This review includes a comprehensive description of the state of the art for CDPS-dependent pathways, and highlights the ways in which this knowledge could be used to increase the diversity of natural DKPs by pathway engineering.
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Dates et versions

hal-03631648 , version 1 (05-04-2022)

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Pascal Belin, Mireille Moutiez, Sylvie Lautru, Jérôme Seguin, Jean-Luc Pernodet, et al.. The nonribosomal synthesis of diketopiperazines in tRNA-dependent cyclodipeptide synthase pathways. Natural Product Reports, 2012, 29 (9), pp.961-979. ⟨10.1039/C2NP20010D⟩. ⟨hal-03631648⟩
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