Dedicated to Jean-Pierre Dutasta and Christian Roussel on the occasion of their retirement and to all scientists who contributed to the development of Chirality in France. Historically, the tremendous role played by French scientists in the importance of chirality in chemistry, physics, biology, medicine, or materials science, starting with the pioneering works and discoveries of Augustin Fresnel, Jean-Baptiste Biot, Louis Pasteur, or Aimé Cotton, has been largely acknowledged by the international scientific community. The French chemists and physicists interested by chirality in the broadest sense continued this tradition over the years by being very actively involved in many chirality related research fields such as enantioselective synthesis and catalysis, analytical and chiral separation techniques, chiroptical spectroscopies, theoretical approaches, supramolecular chemistry, polymers, biomimetic systems, chiral materials, and fundamental physics. Witnessing the ever growing interest in France of this interdisciplinary topic, a French network in chirality supported by the CNRS (GDR Chirafun),gathering about 30 chemistry and physics teams from different Institutes, has emerged in 2015, following the organization of the "André Collet Chirality Days" in 2009 and2012, which were then continued in 2015 and 2018 under the auspices of the Chirafun network, with a new edition planned for October 2022.In this year 2022 marking the bicentenary of Louis Pasteur's birth, we are deeply pleased and honored to introduce this special virtual issue of Chirality gathering 19 very high quality articles spanning different chirality related fields covering