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Article Dans Une Revue Frontiers in Immunology Année : 2022

Plasma Markers of Neutrophil Extracellular Trap Are Linked to Survival but Not to Pulmonary Embolism in COVID-19-Related ARDS Patients

Renaud Prevel (1, 2, 3, 4) , Annabelle Dupont (5, 6) , S. Labrouche-Colomer (7) , Geoffrey Garcia (8) , Antoine Dewitte (9, 3, 10, 11, 7) , Antoine Rauch (12, 13, 5, 6) , Julien Goutay (5) , Morgan Caplan (5) , E. Jozefowicz (5) , Jean-Philippe Lanoix (14, 15) , Julien Poissy (16, 17, 5, 18, 19) , Etienne Riviere (7) , Arthur Orieux (2, 20, 4) , Denis Malvy (2, 21, 22, 3, 4, 23, 24, 25) , Didier Gruson (1, 2, 26, 3, 27) , Loic Garcon (28, 29, 14, 30, 27, 27, 8) , Sophie Susen (31, 12, 5, 13, 5, 6) , Chloé James (32, 20, 3, 33, 7)
1 MFP - Microbiologie Fondamentale et Pathogénicité
2 Hôpital Pellegrin
3 CHU Bordeaux
4 CHU de Bordeaux Pellegrin [Bordeaux]
5 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
6 RNMCD - Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011
7 Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
8 HEMATIM - HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666
9 BIOTIS - Bioingénierie tissulaire
10 Service Anesthésie - Réanimation [Bordeaux]
11 ImmunoConcept - Immunology from Concept and Experiments to Translation
12 Interface sang vaisseaux et réparation cardiovasculaire
13 EGID - Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508
14 CHU Amiens-Picardie
15 AGIR - Agents infectieux, résistance et chimiothérapie - UR UPJV 4294
16 CIIL - Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204
17 Hôpital Roger Salengro [Lille]
18 UGSF - Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576
19 UNIL - Université de Lausanne = University of Lausanne
20 UB - Université de Bordeaux
21 Service de médecine interne et maladies tropicales
22 Epidémiologie et Biostatistique [Bordeaux]
23 Université Victor Segalen - Bordeaux 2
24 BPH - Bordeaux population health
25 GHiGS - Global Health in the Global South
26 CRCTB - Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux]
27 CHU Saint-Antoine [AP-HP]
28 Laboratoire d'Hématologie [CHU Amiens]
29 UPJV - Université de Picardie Jules Verne
30 AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)
31 Hôpital cardiologique
32 University of Salford
33 CHU Pessac

Résumé

ntroduction: Coronavirus disease 2019 (COVID-19) can cause life-threatening acute respiratory distress syndrome (ARDS). Recent data suggest a role for neutrophil extracellular traps (NETs) in COVID-19-related lung damage partly due to microthrombus formation. Besides, pulmonary embolism (PE) is frequent in severe COVID-19 patients, suggesting that immunothrombosis could also be responsible for increased PE occurrence in these patients. Here, we evaluate whether plasma levels of NET markers measured shorty after admission of hospitalized COVID-19 patients are associated with clinical outcomes in terms of clinical worsening, survival, and PE occurrence. Patients and Methods: Ninety-six hospitalized COVID-19 patients were included, 50 with ARDS (severe disease) and 46 with moderate disease. We collected plasma early after admission and measured 3 NET markers: total DNA, myeloperoxidase (MPO)–DNA complexes, and citrullinated histone H3. Comparisons between survivors and non-survivors and patients developing PE and those not developing PE were assessed by Mann–Whitney test. Results: Analysis in the whole population of hospitalized COVID-19 patients revealed increased circulating biomarkers of NETs in patients who will die from COVID-19 and in patients who will subsequently develop PE. Restriction of our analysis in the most severe patients, i.e., the ones who enter the hospital for COVID-19-related ARDS, confirmed the link between NET biomarker levels and survival but not PE occurrence. Conclusion: Our results strongly reinforce the hypothesis that NETosis is an attractive therapeutic target to prevent COVID-19 progression but that it does not seem to be linked to PE occurrence in patients hospitalized with COVID-19.
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hal-03626002 , version 1 (31-03-2022)

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Renaud Prevel, Annabelle Dupont, S. Labrouche-Colomer, Geoffrey Garcia, Antoine Dewitte, et al.. Plasma Markers of Neutrophil Extracellular Trap Are Linked to Survival but Not to Pulmonary Embolism in COVID-19-Related ARDS Patients. Frontiers in Immunology, 2022, 13, pp.851497. ⟨10.3389/fimmu.2022.851497⟩. ⟨hal-03626002⟩
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