Predictors of Functional Impairment in Bipolar Disorder: Results from 13 Cohorts from Seven Countries by The Global Bipolar Cohort Collaborative
K. Burdick
(1)
,
C. Millett
(1)
,
A. Yocum
(2)
,
C. Altimus
(3)
,
O. Andreassen
(4)
,
V. Aubin
(5)
,
R. Belzeaux
(6, 7, 8)
,
M. Berk
(9, 10)
,
J. Biernacka
(11)
,
H. Blumberg
(12)
,
A. Cleare
(13)
,
C. Diaz‐byrd
(2)
,
C. Dubertret
(14, 15)
,
B. Etain
(16, 17)
,
L. Eyler
(18)
,
B. Forester
(19)
,
J. Fullerton
(20)
,
M. Frye
(11)
,
S. Gard
(21)
,
O. Godin
(22, 23, 24, 25)
,
E. Haffen
(26)
,
F. Klaus
(18)
,
T. Lagerberg
(4)
,
M. Leboyer
(27, 22, 23)
,
A. Martinez‐aran
(28)
,
S. Mcelroy
(29)
,
P. Mitchell
(20)
,
Émilie Olié
(30, 8)
,
P. Olorunfemi
(31)
,
C. Passerieux
(32, 33)
,
A. Peters
(31)
,
D. Pham
(3)
,
M. Polosan
(34, 35)
,
J. Potter
(1)
,
M. Sajatovic
(36)
,
L. Samalin
(37, 38)
,
R. Schwan
(39)
,
M. Shanahan
(1)
,
B. Solé
(28)
,
R. Strawbridge
(13)
,
A. Stuart
(9)
,
I. Torres
(40)
,
T. Ueland
(4, 41)
,
E. Vieta
(28)
,
L. Williams
(9, 42)
,
A. Wrobel
(9, 10)
,
L. Yatham
(40)
,
A. Young
(13)
,
A. Nierenberg
(31)
,
M. Mcinnis
(2)
1
HMS -
Harvard Medical School [Boston]
2 University of Michigan [Ann Arbor]
3 Milken Institute School of Public Health
4 NORMENT - Norwegian Centre for Mental Disorders Research [Oslo]
5 Centre Hospitalier Princesse Grace
6 APHM - Assistance Publique - Hôpitaux de Marseille
7 INT - Institut de Neurosciences de la Timone
8 IGF - Institut de Génomique Fonctionnelle
9 Deakin University [Burwood]
10 Orygen Youth Health Research Centre [Melbourne]
11 Mayo Clinic [Rochester]
12 YSM - Yale School of Medicine [New Haven, Connecticut]
13 King‘s College London
14 IPNP - U1266 Inserm - Institut de psychiatrie et neurosciences de Paris
15 Hôpital Louis Mourier - AP-HP [Colombes]
16 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
17 Hôpital Lariboisière-Fernand-Widal [APHP]
18 UC San Diego - University of California [San Diego]
19 McLean Hospital [Belmont, Ma.]
20 UNSW - University of New South Wales [Sydney]
21 Centre hospitalier Charles Perrens [Bordeaux]
22 CHU Henri Mondor [Créteil]
23 Fondation FondaMental [Créteil]
24 U955 Inserm - UPEC - IMRB - "Neuropsychiatrie translationnelle" [Créteil]
25 UPEC Médecine - Université Paris-Est Créteil Val-de-Marne - Faculté de médecine
26 UBFC - Université Bourgogne Franche-Comté [COMUE]
27 IMRB - Institut Mondor de Recherche Biomédicale
28 CIBER-SAM - Centro de Investigación Biomédica en Red Salud Mental [Madrid]
29 University of Cincinnati College of Medicine
30 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
31 Massachusetts General Hospital [Boston]
32 CHV - Centre Hospitalier de Versailles André Mignot
33 CESP - Centre de recherche en épidémiologie et santé des populations
34 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
35 GIN - [GIN] Grenoble Institut des Neurosciences
36 Case Western Reserve University [Cleveland]
37 CHU Clermont-Ferrand
38 IP - Institut Pascal
39 UL - Université de Lorraine
40 UBC - University of British Columbia
41 UiO - University of Oslo
42 Barwon Health - IMPACT Strategic Research Centre [VIC, Australia]
2 University of Michigan [Ann Arbor]
3 Milken Institute School of Public Health
4 NORMENT - Norwegian Centre for Mental Disorders Research [Oslo]
5 Centre Hospitalier Princesse Grace
6 APHM - Assistance Publique - Hôpitaux de Marseille
7 INT - Institut de Neurosciences de la Timone
8 IGF - Institut de Génomique Fonctionnelle
9 Deakin University [Burwood]
10 Orygen Youth Health Research Centre [Melbourne]
11 Mayo Clinic [Rochester]
12 YSM - Yale School of Medicine [New Haven, Connecticut]
13 King‘s College London
14 IPNP - U1266 Inserm - Institut de psychiatrie et neurosciences de Paris
15 Hôpital Louis Mourier - AP-HP [Colombes]
16 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
17 Hôpital Lariboisière-Fernand-Widal [APHP]
18 UC San Diego - University of California [San Diego]
19 McLean Hospital [Belmont, Ma.]
20 UNSW - University of New South Wales [Sydney]
21 Centre hospitalier Charles Perrens [Bordeaux]
22 CHU Henri Mondor [Créteil]
23 Fondation FondaMental [Créteil]
24 U955 Inserm - UPEC - IMRB - "Neuropsychiatrie translationnelle" [Créteil]
25 UPEC Médecine - Université Paris-Est Créteil Val-de-Marne - Faculté de médecine
26 UBFC - Université Bourgogne Franche-Comté [COMUE]
27 IMRB - Institut Mondor de Recherche Biomédicale
28 CIBER-SAM - Centro de Investigación Biomédica en Red Salud Mental [Madrid]
29 University of Cincinnati College of Medicine
30 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
31 Massachusetts General Hospital [Boston]
32 CHV - Centre Hospitalier de Versailles André Mignot
33 CESP - Centre de recherche en épidémiologie et santé des populations
34 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
35 GIN - [GIN] Grenoble Institut des Neurosciences
36 Case Western Reserve University [Cleveland]
37 CHU Clermont-Ferrand
38 IP - Institut Pascal
39 UL - Université de Lorraine
40 UBC - University of British Columbia
41 UiO - University of Oslo
42 Barwon Health - IMPACT Strategic Research Centre [VIC, Australia]
K. Burdick
- Fonction : Auteur
- PersonId : 824233
- ORCID : 0000-0003-4417-4988
C. Millett
- Fonction : Auteur
- PersonId : 824193
- ORCID : 0000-0003-0072-5522
J. Biernacka
- Fonction : Auteur
- PersonId : 805585
- ORCID : 0000-0001-9350-4440
H. Blumberg
- Fonction : Auteur
- PersonId : 805586
- ORCID : 0000-0002-6363-4698
B. Etain
- Fonction : Auteur
- PersonId : 757741
- IdHAL : bruno-etain
- ORCID : 0000-0002-5377-1488
- IdRef : 074181106
J. Fullerton
- Fonction : Auteur
- PersonId : 792529
- ORCID : 0000-0003-4014-4490
O. Godin
- Fonction : Auteur
- PersonId : 1093297
- IdHAL : ophelia-godin
- ORCID : 0000-0001-5004-5475
M. Leboyer
- Fonction : Auteur
- PersonId : 756830
- ORCID : 0000-0001-5473-3697
- IdRef : 089352475
Émilie Olié
- Fonction : Auteur
- PersonId : 975700
C. Passerieux
- Fonction : Auteur
- PersonId : 1234382
- ORCID : 0000-0003-4130-1590
A. Peters
- Fonction : Auteur
- PersonId : 755326
- ORCID : 0000-0003-0224-647X
J. Potter
- Fonction : Auteur
- PersonId : 755340
- ORCID : 0000-0002-4679-0269
M. Sajatovic
- Fonction : Auteur
- PersonId : 824235
- ORCID : 0000-0002-3073-668X
R. Strawbridge
- Fonction : Auteur
- PersonId : 824236
- ORCID : 0000-0002-2984-1124
T. Ueland
- Fonction : Auteur
E. Vieta
- Fonction : Auteur
- PersonId : 785945
- ORCID : 0000-0003-1673-8248
L. Williams
- Fonction : Auteur
- PersonId : 759575
- ORCID : 0000-0002-1377-1272
A. Wrobel
- Fonction : Auteur
- PersonId : 824237
- ORCID : 0000-0002-1864-0394
A. Nierenberg
- Fonction : Auteur
- PersonId : 807097
- ORCID : 0000-0003-2897-0458
Résumé
Objectives: Persistent functional impairment is common in bipolar disorder (BD) and is influenced by a number of demographic, clinical, and cognitive features. The goal of this project was to estimate and compare the influence of key factors on community function in multiple cohorts of well-characterized samples of individuals with BD.
Methods: Thirteen cohorts from 7 countries included n=5,882 individuals with BD across multiple sites. The statistical approach consisted of a systematic uniform application of analyses across sites. Each site performed a logistic regression analysis with empirically derived "higher versus lower function" as the dependent variable and selected clinical and demographic variables as predictors.
Results: We found high rates of functional impairment, ranging from 41-75%. Lower community functioning was associated with depressive symptoms in 10 of 12 of the cohorts that included this variable in the analysis. Lower levels of education, a greater number of prior mood episodes, presence of a comorbid substance use disorder, and a greater total number of psychotropic medications were also associated with low functioning.
Conclusions: The bipolar clinical research community is poised to work together to characterize the multi-dimensional contributors to impairment and address the barriers that impede patients' complete recovery. We must also identify the core features which enable many to thrive and live successfully with BD. A large-scale, worldwide, prospective longitudinal study focused squarely on BD and its heterogeneous presentations will serve as a platform for discovery and promote major advances toward optimizing outcomes for every individual with this illness.
Fichier principal
Bipolar Disorders - 2022 - Burdick - Predictors of functional impairment in bipolar disorder Results from 13 cohorts from.pdf (614.73 Ko)
Télécharger le fichier
| Origine | Fichiers éditeurs autorisés sur une archive ouverte |
|---|
