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Article Dans Une Revue (Data Paper) Bipolar Disorders Année : 2022

Predictors of Functional Impairment in Bipolar Disorder: Results from 13 Cohorts from Seven Countries by The Global Bipolar Cohort Collaborative

1 HMS - Harvard Medical School [Boston]
2 University of Michigan [Ann Arbor]
3 Milken Institute School of Public Health
4 NORMENT - Norwegian Centre for Mental Disorders Research [Oslo]
5 Centre Hospitalier Princesse Grace
6 APHM - Assistance Publique - Hôpitaux de Marseille
7 INT - Institut de Neurosciences de la Timone
8 Deakin University [Burwood]
9 Orygen Youth Health Research Centre [Melbourne]
10 Mayo Clinic [Rochester]
11 YSM - Yale School of Medicine [New Haven, Connecticut]
12 King‘s College London
13 IPNP - U1266 Inserm - Institut de psychiatrie et neurosciences de Paris
14 Hôpital Louis Mourier - AP-HP [Colombes]
15 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
16 Hôpital Lariboisière-Fernand-Widal [APHP]
17 UC San Diego - University of California [San Diego]
18 McLean Hospital [Belmont, Ma.]
19 UNSW - University of New South Wales [Sydney]
20 Centre hospitalier Charles Perrens [Bordeaux]
21 IMRB - Institut Mondor de Recherche Biomédicale
22 CHU Henri Mondor [Créteil]
23 Fondation FondaMental [Créteil]
24 UBFC - Université Bourgogne Franche-Comté [COMUE]
25 CIBER-SAM - Centro de Investigación Biomédica en Red Salud Mental [Madrid]
26 University of Cincinnati College of Medicine
27 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
28 IGF - Institut de Génomique Fonctionnelle
29 Massachusetts General Hospital [Boston]
30 CHV - Centre Hospitalier de Versailles André Mignot
31 CESP - Centre de recherche en épidémiologie et santé des populations
32 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
33 GIN - [GIN] Grenoble Institut des Neurosciences
34 Case Western Reserve University [Cleveland]
35 CHU Clermont-Ferrand
36 IP - Institut Pascal
37 UL - Université de Lorraine
38 UBC - University of British Columbia
39 UiO - University of Oslo
40 Barwon Health - IMPACT Strategic Research Centre [VIC, Australia]
K. Burdick
C. Millett
J. Biernacka
A. Cleare
J. Fullerton
M. Frye
  • Fonction : Auteur
A. Peters
J. Potter
R. Strawbridge
A. Young
  • Fonction : Auteur
A. Nierenberg

Résumé

Objectives: Persistent functional impairment is common in bipolar disorder (BD) and is influenced by a number of demographic, clinical, and cognitive features. The goal of this project was to estimate and compare the influence of key factors on community function in multiple cohorts of well-characterized samples of individuals with BD. Methods: Thirteen cohorts from 7 countries included n=5,882 individuals with BD across multiple sites. The statistical approach consisted of a systematic uniform application of analyses across sites. Each site performed a logistic regression analysis with empirically derived "higher versus lower function" as the dependent variable and selected clinical and demographic variables as predictors. Results: We found high rates of functional impairment, ranging from 41-75%. Lower community functioning was associated with depressive symptoms in 10 of 12 of the cohorts that included this variable in the analysis. Lower levels of education, a greater number of prior mood episodes, presence of a comorbid substance use disorder, and a greater total number of psychotropic medications were also associated with low functioning. Conclusions: The bipolar clinical research community is poised to work together to characterize the multi-dimensional contributors to impairment and address the barriers that impede patients' complete recovery. We must also identify the core features which enable many to thrive and live successfully with BD. A large-scale, worldwide, prospective longitudinal study focused squarely on BD and its heterogeneous presentations will serve as a platform for discovery and promote major advances toward optimizing outcomes for every individual with this illness.
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Dates et versions

hal-03625156 , version 1 (30-05-2022)

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Paternité - Pas d'utilisation commerciale - Pas de modification

Identifiants

Citer

K. Burdick, C. Millett, A. Yocum, C. Altimus, O. Andreassen, et al.. Predictors of Functional Impairment in Bipolar Disorder: Results from 13 Cohorts from Seven Countries by The Global Bipolar Cohort Collaborative. Bipolar Disorders, 2022, 24 (7), pp.709-719. ⟨10.1111/bdi.13208⟩. ⟨hal-03625156⟩
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