Iridium‐Catalyzed β‐C(sp 2 )−H Borylation of Enamides – Access to 3,3‐Dihalogeno‐2‐methoxypiperidines - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue European Journal of Organic Chemistry Année : 2022

Iridium‐Catalyzed β‐C(sp 2 )−H Borylation of Enamides – Access to 3,3‐Dihalogeno‐2‐methoxypiperidines

Résumé

An efficient iridium-catalyzed C(sp2)−H reaction of non-aromatic tertiary enamides was successfully developed under mild reaction conditions and with high regioselectivity, leading to original C-3 borylated enamides in good yields. These derivatives could then be exploited in Suzuki cross-coupling reactions, or converted into valuable 3,3-dihalogenopiperidine derivatives through short reaction times with moderate to good yields.
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Dates et versions

hal-03624937 , version 1 (30-03-2022)

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Isabelle Gillaizeau, Ismaël Dondasse, Cyril Nicolas, Liliane Mimoun, Volodymyr Sukach, et al.. Iridium‐Catalyzed β‐C(sp 2 )−H Borylation of Enamides – Access to 3,3‐Dihalogeno‐2‐methoxypiperidines. European Journal of Organic Chemistry, 2022, 2022 (2), ⟨10.1002/ejoc.202101302⟩. ⟨hal-03624937⟩
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