The progress in communication technologies and data storage capacity has brought tremendous changes in our daily life and also in the city where we live. The city becomes smart and has to integrate innovative applications, and technology to improve the quality of life of its citizens. To experiment and estimate these innovations, we show that a university campus is a ground “in vivo” experiments adequate. The infrastructure deployed in the Toulouse III Paul Sabatier University campus, enabling its transformation in a smart and sustainable campus, is detailed. The approach to answer the main challenges a smart campus has to deal with, is described. Some challenges are illustrated with a case study on the balance between the energy efficiency and the comfort in a class.