Dihydroxylated E,E,Z-docosatrienes. An overview of their synthesis and biological significance - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Progress in Lipid Research Année : 2016

Dihydroxylated E,E,Z-docosatrienes. An overview of their synthesis and biological significance

Résumé

Dihydroxylated E,E,Z-docosatrienes are acyclic lipoxygenase metabolites of 22-carbon atom polyunsaturated fatty acids (PUFAs) containing a conjugated E,E,Z-triene flanked by two secondary allylic alcohols. The two main metabolites, protectin D1 (PD1) and its regioisomer maresin 1 (MaR1), were shown to be actively involved in the resolution and more specifically the termination of the inflammation process. Studies directed at the synthesis of E,E,Z-docosatrienes have been undertaken to resolve stereochemical ambiguities, and provide standards for biological evaluation and reference samples for in-vivo detection and lipidomic analyses. In this review we provide a brief update of the literature on the biological significance of E,E,Z-docosatrienes and the role that synthetic organic chemists has played in the development of these lipids, providing an overview and comparison of the different strategies employed to access synthetic E,E,Z-docosatriene standards.

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Chimie
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Dates et versions

hal-03624190 , version 1 (30-03-2022)

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Laurence Balas, Thierry Durand. Dihydroxylated E,E,Z-docosatrienes. An overview of their synthesis and biological significance. Progress in Lipid Research, 2016, 61, pp.1-18. ⟨10.1016/j.plipres.2015.10.002⟩. ⟨hal-03624190⟩
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