Article Dans Une Revue Clinical Neurophysiology Année : 2019

A 15-day course of donepezil modulates spectral EEG dynamics related to target auditory stimuli in young, healthy adult volunteers

Déborah Méligne
Laura Lanteaume
  • Fonction : Auteur
François Guimont
  • Fonction : Auteur
Catherine Cassé-Perrot
  • Fonction : Auteur
Franck Rouby
  • Fonction : Auteur
Régis Bordet
Philippe Derambure
  • Fonction : Auteur

Résumé

Objective To identify possible electroencephalographic (EEG) markers of donepezil’s effect on cortical activity in young, healthy adult volunteers at the group level. Methods Thirty subjects were administered a daily dose of either 5 mg donepezil or placebo for 15 days in a double-blind, randomized, cross-over trial. The electroencephalogram during an auditory oddball paradigm was recorded from 58 scalp electrodes. Current source density (CSD) transformations were applied to EEG epochs. The event-related potential (ERP), inter-trial coherence (ITC: the phase consistency of the EEG spectrum) and event-related spectral perturbation (ERSP: the EEG power spectrum relative to the baseline) were calculated for the target (oddball) stimuli. Results The donepezil and placebo conditions differed in terms of the changes in delta/theta/alpha/beta ITC and ERSP in various regions of the scalp (especially the frontal electrodes) but not in terms of latency and amplitude of the P300-ERP component. Conclusion Our results suggest that ITC and ERSP analyses can provide EEG markers of donepezil’s effects in young, healthy, adult volunteers at a group level. Significance Novel EEG markers could be useful to assess the therapeutic potential of drug candidates in Alzheimer’s disease in healthy volunteers prior to the initiation of Phase II/III clinical studies in patients.

Dates et versions

hal-03623862 , version 1 (29-03-2022)

Identifiants

Citer

Christopher Leroy, Jean-Louis Bourriez, Kathy Dujardin, Behnam Molaee-Ardekani, Claudio Babiloni, et al.. A 15-day course of donepezil modulates spectral EEG dynamics related to target auditory stimuli in young, healthy adult volunteers. Clinical Neurophysiology, 2019, 130 (5), pp.863-875. ⟨10.1016/j.clinph.2015.11.018⟩. ⟨hal-03623862⟩
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