The frequency and influence of dementia risk factors in prodromal Alzheimer's disease
Isabelle Bos
(1)
,
Stephanie Vos
(1)
,
Lutz Frölich
(2)
,
Johannes Kornhuber
(3)
,
Jens Wiltfang
(4)
,
Wolfgang Maier
(5)
,
Oliver Peters
(6)
,
Eckhart Rüther
(4)
,
Sebastiaan Engelborghs
(7)
,
Ellis Niemantsverdriet
(7)
,
Ellen Elisa de Roeck
(7, 8)
,
Magda Tsolaki
(9)
,
Yvonne Freund-Levi
(10)
,
Peter Johannsen
(11)
,
Rik Vandenberghe
(12)
,
Alberto Lleó
(13)
,
Daniel Alcolea
(13)
,
Giovanni Frisoni
(14, 15)
,
Samantha Galluzzi
(15)
,
Flavio Nobili
(16)
,
Silvia Morbelli
(16)
,
Alexander Drzezga
(17)
,
Mira Didic
(18, 19)
,
Bart van Berckel
(20)
,
Eric Salmon
(21, 22)
,
Christine Bastin
(22)
,
Solene Dauby
(21)
,
Isabel Santana
(21)
,
Inês Baldeiras
(23)
,
Alexandre de Mendonça
(24)
,
Dina Silva
(24)
,
Anders Wallin
(25)
,
Arto Nordlund
(25)
,
Preciosa Coloma
(26)
,
Angelika Wientzek
(27)
,
Myriam Alexander
(27)
,
Gerald Novak
(28)
,
Mark Forrest Gordon
(29)
,
Åsa Wallin
(30)
,
Harald Hampel
(31, 32, 31)
,
Hilkka Soininen
(33)
,
Sanna-Kaisa Herukka
(33)
,
Philip Scheltens
(20)
,
Frans Verhey
(1)
,
Pieter Jelle Visser
(1)
1
Maastricht University [Maastricht]
2 Universität Heidelberg [Heidelberg] = Heidelberg University
3 FAU - Friedrich-Alexander Universität Erlangen-Nürnberg = University of Erlangen-Nuremberg
4 Georg-August-University = Georg-August-Universität Göttingen
5 Universität Bonn = University of Bonn
6 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
7 UA - University of Antwerp
8 VUB - Vrije Universiteit Brussel
9 Aristotle University of Thessaloniki
10 Karolinska Institutet [Stockholm]
11 Copenhagen University Hospital
12 KU Leuven - Catholic University of Leuven = Katholieke Universiteit Leuven
13 Hospital de la Santa Creu i Sant Pau
14 UNIGE - Université de Genève = University of Geneva
15 IRCCS - Centro San Giovanni di Dio, Fatebenefratelli, Brescia
16 UniGe - Università degli studi di Genova = University of Genoa
17 University of Cologne
18 INS - Institut de Neurosciences des Systèmes
19 TIMONE - Hôpital de la Timone [CHU - APHM]
20 VU University Medical Center [Amsterdam]
21 CHU-Liège - Centre Hospitalier Universitaire de Liège
22 Université de Liège
23 Centro Hospitalar e Universitário [Coimbra]
24 Université de Lisbonne
25 GU - Göteborgs Universitet = University of Gothenburg
26 F. Hoffmann-La Roche [Basel]
27 Roche Products Ltd
28 Janssen Research & Development
29 Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield
30 Skane University Hospital [Lund]
31 CHU Pitié-Salpêtrière [AP-HP]
32 ICM - Institut du Cerveau = Paris Brain Institute
33 University of Eastern Finland
2 Universität Heidelberg [Heidelberg] = Heidelberg University
3 FAU - Friedrich-Alexander Universität Erlangen-Nürnberg = University of Erlangen-Nuremberg
4 Georg-August-University = Georg-August-Universität Göttingen
5 Universität Bonn = University of Bonn
6 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
7 UA - University of Antwerp
8 VUB - Vrije Universiteit Brussel
9 Aristotle University of Thessaloniki
10 Karolinska Institutet [Stockholm]
11 Copenhagen University Hospital
12 KU Leuven - Catholic University of Leuven = Katholieke Universiteit Leuven
13 Hospital de la Santa Creu i Sant Pau
14 UNIGE - Université de Genève = University of Geneva
15 IRCCS - Centro San Giovanni di Dio, Fatebenefratelli, Brescia
16 UniGe - Università degli studi di Genova = University of Genoa
17 University of Cologne
18 INS - Institut de Neurosciences des Systèmes
19 TIMONE - Hôpital de la Timone [CHU - APHM]
20 VU University Medical Center [Amsterdam]
21 CHU-Liège - Centre Hospitalier Universitaire de Liège
22 Université de Liège
23 Centro Hospitalar e Universitário [Coimbra]
24 Université de Lisbonne
25 GU - Göteborgs Universitet = University of Gothenburg
26 F. Hoffmann-La Roche [Basel]
27 Roche Products Ltd
28 Janssen Research & Development
29 Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield
30 Skane University Hospital [Lund]
31 CHU Pitié-Salpêtrière [AP-HP]
32 ICM - Institut du Cerveau = Paris Brain Institute
33 University of Eastern Finland
Johannes Kornhuber
- Fonction : Auteur
- PersonId : 776431
- ORCID : 0000-0002-8096-3987
Jens Wiltfang
- Fonction : Auteur
- PersonId : 776430
- ORCID : 0000-0003-1492-5330
Oliver Peters
- Fonction : Auteur
- PersonId : 776429
- ORCID : 0000-0003-0568-2998
Ellen Elisa de Roeck
- Fonction : Auteur
- PersonId : 824186
- ORCID : 0000-0002-6566-6562
Yvonne Freund-Levi
- Fonction : Auteur
- PersonId : 801316
- ORCID : 0000-0001-6863-6679
Alberto Lleó
- Fonction : Auteur
- PersonId : 792181
- ORCID : 0000-0002-2568-5478
Daniel Alcolea
- Fonction : Auteur
- PersonId : 797376
- ORCID : 0000-0002-3819-3245
Giovanni Frisoni
- Fonction : Auteur
- PersonId : 768850
- ORCID : 0000-0001-7075-7082
Flavio Nobili
- Fonction : Auteur
- PersonId : 785159
- ORCID : 0000-0001-9811-0897
Mira Didic
- Fonction : Auteur
- PersonId : 757436
- ORCID : 0000-0001-7067-536X
Mark Forrest Gordon
- Fonction : Auteur
- PersonId : 824187
- ORCID : 0000-0002-0271-3050
Harald Hampel
- Fonction : Auteur
- PersonId : 1154848
- IdHAL : harald-hampel
- ORCID : 0000-0003-0894-8982
- IdRef : 16155007X
Hilkka Soininen
- Fonction : Auteur
- PersonId : 763717
- ORCID : 0000-0002-2785-9937
Pieter Jelle Visser
- Fonction : Auteur
- PersonId : 785160
- ORCID : 0000-0001-8008-9727
Résumé
We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Cox-regression to examine the effect of risk factors on cognitive decline. Depression, obesity, and hypercholesterolemia occurred more often in individuals with low-AD-likelihood, compared with those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with mild cognitive impairment. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e., preclinical) of AD.