In this article, both numerical and experimental investigations were carried out on the durability of hemp concrete. For this, an accelerated aging process was performed using cycles of immersion, freezing and drying. Then, an experimental campaign was enabled to determine heat and mass transfer properties, as well as the microstructure for both aged and reference materials. Observations using a digital microscope showed the appearance of cracks at the interfaces and an increase of the porosity of about 6%. These microstructural modifications imply a non-negligible evolution of heat and mass transfer properties. Thus, a numerical model for the prediction of heat and mass transfer was developed. The prediction of physical phenomena was computed using both aged and reference material properties. It highlights the aging effects on the behaviour of the hemp concrete. The numerical simulation results showed significant discrepancies between the predicted relative humidity values for the two configurations (aged and reference) of about 18% and a maximum phase shift of 40 min, due to the amplification of the mass transfer kinetics after aging. Nevertheless, few deviations in temperature values were found. Thus, after aging, sensible heat fluxes were overestimated compared to the reference case, unlike latent heat fluxes, where an underestimation was shown.