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Article Dans Une Revue Advances in Experimental Medicine and Biology Année : 2022

Role of central/peripheral chemoreceptors and their interdependence in the pathophysiology of sleep apnea.

Jerome Dempsey
  • Fonction : Auteur
Curtis Smith
  • Fonction : Auteur
Ailiang Xie
  • Fonction : Auteur
Yuansheng Gong
  • Fonction : Auteur
Mihaela Teodorescu
  • Fonction : Auteur

Résumé

Unstable periodic breathing with intermittent ventilatory overshoots and undershoots commonly occurs in chronic heart failure, in hypoxia, with chronic opioid use and in certain types of obstructive sleep apnea. Sleep promotes breathing instability because it unmasks a highly sensitive dependence of the respiratory control system on chemoreceptor input, because transient cortical arousals promote ventilatory overshoots and also because upper airway dilator muscle tonicity is reduced and airway collapsibility enhanced. We will present data in support of the premise that carotid chemoreceptors are essential in the pathogenesis of apnea and periodicity; however it is the hyperadditive influence of peripheral chemoreceptor sensory input on central chemosensitivity that accounts for apnea and periodic breathing. This chemoreceptor interdependence also provides a significant portion of the normal drive to breathe in normoxia (i.e. eupnea) and in acute hypoxia. Finally, we discuss the effects of preventing transient hypocapnia (via selective increases in FICO(2)) on centrally mediated types of periodic breathing and even some varieties of cyclical obstructive sleep apnea.
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Dates et versions

hal-03618691 , version 1 (24-03-2022)

Identifiants

Citer

Jerome Dempsey, Curtis Smith, Gregory Blain, Ailiang Xie, Yuansheng Gong, et al.. Role of central/peripheral chemoreceptors and their interdependence in the pathophysiology of sleep apnea.. Advances in Experimental Medicine and Biology, 2022, 758, pp.343-9. ⟨10.1007/978-94-007-4584-1_46⟩. ⟨hal-03618691⟩
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