Two-dimensional materials have gained significant attention across the materials community due to their remarkable physical, chemical, electronic, and optical properties. With many two-dimensional materials discovered each year, investigations into their processing, scalability, and resulting properties are important to fully realize their potential in next-generation technologies. While numerous exfoliation techniques are available for a variety of two-dimensional materials, liquid-phase exfoliation techniques offer many advantages, particularly high throughput and scalability. Herein, we report a liquid-phase exfoliation method to access multilayer cobalt oxide nanosheets in pH-neutral aqueous solutions varying in size, concentration, and application. The size, thickness, and morphology of the multilayer nanosheets were confirmed using atomic forcemicroscopy and transmission electron microscopy. Finally, selected cobalt oxide nanosheets underwent additional analysis of the crystallinity, structure, and cobalt valance.