Personalized medicine for allergy treatment: Allergen immunotherapy still a unique and unmatched model
Cristoforo Incorvaia
(1)
,
Mona Al‐ahmad
(2, 3)
,
Ignacio Ansotegui
(4)
,
Stefania Arasi
(5)
,
Claus Bachert
(6, 7, 8)
,
Catherine Bos
(9)
,
Jean Bousquet
(10, 11)
,
Andrzéj Bozek
(12)
,
Davide Caimmi
(13, 14)
,
Moises Calderón
(15)
,
Thomas Casale
(16)
,
Adnan Custovic
(17)
,
Frédéric de Blay
(18)
,
Pascal Demoly
(14, 13, 19)
,
Philippe Devillier
(20, 21)
,
Alain Didier
(22)
,
Alessandro Fiocchi
(5)
,
Adam Fox
(23)
,
Philippe Gevaert
(6)
,
Maximiliano Gomez
,
Enrico Heffler
(24, 25)
,
Natalia Ilina
(26)
,
Carla Irani
(27)
,
Marek Jutel
(28)
,
Efstrathios Karagiannis
(9)
,
Ludger Klimek
(29)
,
Piotr Kuna
(30)
,
Robin O'Hehir
(31)
,
Oxana Kurbacheva
(32)
,
Paolo Matricardi
(33)
,
Mario Morais‐almeida
(34)
,
Ralph Mosges
(35, 36)
,
Natalija Novak
(37)
,
Yoshitaka Okamoto
(38)
,
Petr Panzner
(39)
,
Nikolaos Papadopoulos
(17, 40)
,
Hae‐sim Park
(41)
,
Giovanni Passalacqua
(42)
,
Ruby Pawankar
(43)
,
Oliver Pfaar
(44)
,
Peter Schmid‐grendelmeier
(45)
,
Silvia Scurati
(9)
,
Miguel Tortajada‐girbés
(46, 47)
,
Carmen Vidal
(48)
,
J. Christian Virchow
(49)
,
Ulrich Wahn
(33)
,
Margitta Worm
(33)
,
Petra Zieglmayer
,
Giorgio Canonica
(24, 25)
1
ASST Pini-CTO
2 Kuwait University
3 Al-Rashed Allergy Center [Kuwait City]
4 Hospital Quirónsalud Bizkaia [Bilbao]
5 IRCCS Ospedale Pediatrico Bambino Gesù = Bambino Gesù Children’s Hospital
6 Ghent University Hospital
7 Karolinska Institutet [Stockholm]
8 Karolinska University Hospital [Stockholm]
9 Stallergenes - Stallergenes SA
10 CHU Montpellier
11 MACVIA-LR - Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon
12 SUM - Medical University of Silesia
13 Hôpital Arnaud de Villeneuve [CHU Montpellier]
14 IDESP - Institut Desbrest de santé publique
15 Imperial College London
16 USF - University of South Florida [Tampa]
17 University of Manchester [Manchester]
18 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
19 EPAR - Epidemiology of Allergic and Respiratory Diseases Department [iPlesp]
20 Hôpital Foch [Suresnes]
21 Université Paris-Saclay
22 Pôle Clinique des Voies respiratoires [CHU Toulouse]
23 Guy's and St Thomas' Hospitals
24 Humanitas Clinical and Research Center [Rozzano, Milan, Italy]
25 Hunimed - Humanitas University [Milan]
26 Federal Institute of Immunology of Russia [Moscou]
27 USJ - Université Saint-Joseph de Beyrouth
28 Wrocław Medical University
29 Center for Rhinology and Allergology = Zentrum für Rhinologie und Allergologie
30 MUL - Medical University of Łódź
31 Monash University [Melbourne]
32 Federal Medical-Biological Agency of Russia
33 Charité - UniversitätsMedizin = Berlin University Medicine
34 Hospital CUF Descobertas
35 University of Cologne
36 Clinical Research International Ltd.
37 University Hospital Bonn
38 Chiba University Hospital
39 UK - Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic]
40 NKUA - National and Kapodistrian University of Athens
41 Ajou University School of Medicine
42 UniGe - Università degli studi di Genova = University of Genoa
43 Nippon Medical School [Tokyo, Japon]
44 Philipps Universität Marburg = Philipps University of Marburg
45 University hospital of Zurich [Zurich]
46 Dr Peset University Hospital
47 UV - Universitat de València
48 CHUS - Complejo Hospitalario Universitario de Santiago de Compostela [Saint-Jacques-de-Compostelle, Espagne]
49 University of Rostock
2 Kuwait University
3 Al-Rashed Allergy Center [Kuwait City]
4 Hospital Quirónsalud Bizkaia [Bilbao]
5 IRCCS Ospedale Pediatrico Bambino Gesù = Bambino Gesù Children’s Hospital
6 Ghent University Hospital
7 Karolinska Institutet [Stockholm]
8 Karolinska University Hospital [Stockholm]
9 Stallergenes - Stallergenes SA
10 CHU Montpellier
11 MACVIA-LR - Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon
12 SUM - Medical University of Silesia
13 Hôpital Arnaud de Villeneuve [CHU Montpellier]
14 IDESP - Institut Desbrest de santé publique
15 Imperial College London
16 USF - University of South Florida [Tampa]
17 University of Manchester [Manchester]
18 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
19 EPAR - Epidemiology of Allergic and Respiratory Diseases Department [iPlesp]
20 Hôpital Foch [Suresnes]
21 Université Paris-Saclay
22 Pôle Clinique des Voies respiratoires [CHU Toulouse]
23 Guy's and St Thomas' Hospitals
24 Humanitas Clinical and Research Center [Rozzano, Milan, Italy]
25 Hunimed - Humanitas University [Milan]
26 Federal Institute of Immunology of Russia [Moscou]
27 USJ - Université Saint-Joseph de Beyrouth
28 Wrocław Medical University
29 Center for Rhinology and Allergology = Zentrum für Rhinologie und Allergologie
30 MUL - Medical University of Łódź
31 Monash University [Melbourne]
32 Federal Medical-Biological Agency of Russia
33 Charité - UniversitätsMedizin = Berlin University Medicine
34 Hospital CUF Descobertas
35 University of Cologne
36 Clinical Research International Ltd.
37 University Hospital Bonn
38 Chiba University Hospital
39 UK - Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic]
40 NKUA - National and Kapodistrian University of Athens
41 Ajou University School of Medicine
42 UniGe - Università degli studi di Genova = University of Genoa
43 Nippon Medical School [Tokyo, Japon]
44 Philipps Universität Marburg = Philipps University of Marburg
45 University hospital of Zurich [Zurich]
46 Dr Peset University Hospital
47 UV - Universitat de València
48 CHUS - Complejo Hospitalario Universitario de Santiago de Compostela [Saint-Jacques-de-Compostelle, Espagne]
49 University of Rostock
Mona Al‐ahmad
- Fonction : Auteur
- PersonId : 810134
- ORCID : 0000-0003-3720-7032
Ignacio Ansotegui
- Fonction : Auteur
- PersonId : 768031
- ORCID : 0000-0002-6942-1511
Stefania Arasi
- Fonction : Auteur
- PersonId : 784659
- ORCID : 0000-0002-8135-0568
Claus Bachert
- Fonction : Auteur
- PersonId : 764671
- ORCID : 0000-0003-4742-1665
Jean Bousquet
- Fonction : Auteur
- PersonId : 757330
- ORCID : 0000-0002-4061-4766
Andrzéj Bozek
- Fonction : Auteur
- PersonId : 808756
- ORCID : 0000-0003-2263-2263
Davide Caimmi
- Fonction : Auteur
- PersonId : 754264
- IdHAL : davidecaimmi
- ORCID : 0000-0003-4481-6194
- IdRef : 190361816
Thomas Casale
- Fonction : Auteur
- PersonId : 768221
- ORCID : 0000-0002-3149-7377
Pascal Demoly
- Fonction : Auteur
- PersonId : 754222
- IdHAL : pascal-demoly
- ORCID : 0000-0001-7827-7964
- IdRef : 03442959X
Philippe Devillier
- Fonction : Auteur
- PersonId : 757986
- ORCID : 0000-0001-6054-1886
Alain Didier
- Fonction : Auteur
- PersonId : 933609
- ORCID : 0000-0001-6230-9706
Alessandro Fiocchi
- Fonction : Auteur
- PersonId : 798507
- ORCID : 0000-0002-2549-0523
Philippe Gevaert
- Fonction : Auteur
- PersonId : 798816
- ORCID : 0000-0002-1629-8468
Maximiliano Gomez
- Fonction : Auteur
Enrico Heffler
- Fonction : Auteur
- PersonId : 1141287
Marek Jutel
- Fonction : Auteur
- PersonId : 798508
- ORCID : 0000-0003-1555-9379
Ludger Klimek
- Fonction : Auteur
- PersonId : 791087
- ORCID : 0000-0002-2455-0192
Piotr Kuna
- Fonction : Auteur
- PersonId : 764328
- ORCID : 0000-0003-2401-0070
Paolo Matricardi
- Fonction : Auteur
- PersonId : 800461
- ORCID : 0000-0001-5485-0324
Mario Morais‐almeida
- Fonction : Auteur
- PersonId : 799503
- ORCID : 0000-0003-1837-2980
Ralph Mosges
- Fonction : Auteur
- PersonId : 774116
- ORCID : 0000-0002-1928-810X
Petr Panzner
- Fonction : Auteur
- PersonId : 767955
- ORCID : 0000-0002-1291-450X
Nikolaos Papadopoulos
- Fonction : Auteur
- PersonId : 763391
- ORCID : 0000-0002-4448-3468
Hae‐sim Park
- Fonction : Auteur
- PersonId : 800808
- ORCID : 0000-0003-2614-0303
Giovanni Passalacqua
- Fonction : Auteur
- PersonId : 767616
- ORCID : 0000-0002-5139-3604
Ruby Pawankar
- Fonction : Auteur
- PersonId : 767956
- ORCID : 0000-0002-3091-7237
Oliver Pfaar
- Fonction : Auteur
- PersonId : 767433
- ORCID : 0000-0003-4374-9639
Peter Schmid‐grendelmeier
- Fonction : Auteur
- PersonId : 801490
- ORCID : 0000-0003-3215-3370
Carmen Vidal
- Fonction : Auteur
- PersonId : 764770
- ORCID : 0000-0002-2844-2754
J. Christian Virchow
- Fonction : Auteur
- PersonId : 795227
- ORCID : 0000-0003-4291-1956
- IdRef : 114358907
Ulrich Wahn
- Fonction : Auteur
- PersonId : 768365
- ORCID : 0000-0002-5723-6132
Margitta Worm
- Fonction : Auteur
- PersonId : 783933
- ORCID : 0000-0002-3449-1245
Petra Zieglmayer
- Fonction : Auteur
Résumé
The introduction of personalized medicine (PM) has been a milestone in the history of medical therapy, because it has revolutionized the previous approach of treating the disease with that of treating the patient. It is known today that diseases can occur in different genetic variants, making specific treatments of proven efficacy necessary for a given endotype. Allergic diseases are particularly suitable for PM, because they meet the therapeutic success requirements, including a known molecular mechanism of the disease, a diagnostic tool for such disease, and a treatment blocking the mechanism. The stakes of PM in allergic patients are molecular diagnostics, to detect specific IgE to single-allergen molecules and to distinguish the causative molecules from those merely cross-reactive, pursuit of patient's treatable traits addressing genetic, phenotypic, and psychosocial features, and omics, such as proteomics, epi-genomics, metabolomics, and breathomics, to forecast patient's responsiveness to therapies, to detect biomarker and mediators, and to verify the disease control. This new approach has already improved the precision of allergy diagnosis and is likely to significantly increase, through the higher performance achieved with the personalized treatment, the effectiveness of allergen immunotherapy by enhancing its already known and unique characteristics of treatment that acts on the causes.
| Origine | Fichiers produits par l'(les) auteur(s) |
|---|