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Article Dans Une Revue NeuroImage Année : 2016

Longitudinal reproducibility of default-mode network connectivity in healthy elderly participants: a multicentric resting-state fMRI study

1 UNITN - Università degli Studi di Trento = University of Trento
2 LENITEM - Neuroimaging and Telemedicine
3 UB - Universitat de Barcelona
4 Universität Duisburg-Essen = University of Duisburg-Essen [Essen]
5 UniGe - Università degli studi di Genova = University of Genoa
6 INT - Institut de Neurosciences de la Timone
7 APHM - Assistance Publique - Hôpitaux de Marseille
8 TCDV - Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046
9 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
10 CRMBM - Centre de résonance magnétique biologique et médicale
11 INS - Institut de Neurosciences des Systèmes
12 TIMONE - Hôpital de la Timone [CHU - APHM]
13 ICHN - Imagerie cérébrale et handicaps neurologiques
14 Verona General Hospital
15 IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer
16 University "G. d'Annunzio" of Chieti-Pescara [Chieti]
17 IRCCS SDN Napoli
18 PARTHENOPE - Università degli Studi di Napoli “Parthenope” = University of Naples
19 UNIPG - Università degli Studi di Perugia = University of Perugia
20 Perugia General Hospital
21 Aristotle University of Thessaloniki
22 Interbalkan Medical Center of Thessaloniki
23 Unicatt - Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma]
24 University Hospital Leipzig = Universitätsklinikum Leipzig
25 VU University Medical Center [Amsterdam]
26 Maastricht University [Maastricht]
27 VUMC - Vrije Universiteit Medical Centre
28 UNIGE - Université de Genève = University of Geneva
Moira Marizzoni
Marco Aiello
  • Fonction : Auteur
Carlo Cavaliere
  • Fonction : Auteur
Roberto Tarducci
Joost Kuijer
Pieter Jelle Visser
Frederik Barkhof

Résumé

To date, limited data are available regarding the inter-site consistency of test-retest reproducibility of functional connectivity measurements, in particular with regard to integrity of the Default Mode Network (DMN) in elderly participants. We implemented a harmonized resting-state fMRI protocol on 13 clinical scanners at 3.0T using vendor-provided sequences. Each site scanned a group of 5 healthy elderly participants twice, at least a week apart. We evaluated inter-site differences and test-retest reproducibility of both temporal signal-to-noise ratio (tSNR) and functional connectivity measurements derived from: i) seed-based analysis (SBA) with seed in the posterior cingulate cortex (PCC), ii) group independent component analysis (ICA) separately for each site (site ICA), and iii) consortium ICA, with group ICA across the whole consortium. Despite protocol harmonization, significant and quantitatively important inter-site differences remained in the tSNR of resting-state fMRI data; these were plausibly driven by hardware and pulse sequence differences across scanners which could not be harmonized. Nevertheless, the tSNR test-retest reproducibility in the consortium was high (ICC=0.81). The DMN was consistently extracted across all sites and analysis methods. While significant inter-site differences in connectivity scores were found, there were no differences in the associated test-retest error. Overall, ICA measurements were more reliable than PCC-SBA, with site ICA showing higher reproducibility than consortium ICA. Across the DMN nodes, the PCC yielded the most reliable measurements (≈4% test-retest error, ICC=0.85), the medial frontal cortex the least reliable (≈12%, ICC=0.82) and the lateral parietal cortices were in between (site ICA). Altogether these findings support usage of harmonized multisite studies of resting-state functional connectivity to characterize longitudinal effects in studies that assess disease progression and treatment response.
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Dates et versions

hal-03609812 , version 1 (15-03-2022)

Identifiants

Citer

Jorge Jovicich, Ludovico Minati, Moira Marizzoni, Rocco Marchitelli, Roser Sala-Llonch, et al.. Longitudinal reproducibility of default-mode network connectivity in healthy elderly participants: a multicentric resting-state fMRI study. NeuroImage, 2016, 124, pp.442-454. ⟨10.1016/j.neuroimage.2015.07.010⟩. ⟨hal-03609812⟩
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