Multigenerational exposure to gamma radiation affects offspring differently over generations in Zebrafish - Archive ouverte HAL
Article Dans Une Revue Aquatic Toxicology Année : 2022

Multigenerational exposure to gamma radiation affects offspring differently over generations in Zebrafish

Résumé

Mutigenerational studies have become of great interest in ecotoxicology and previously provided original results on the effects of offspring irradiation in model fish Danio rerio. Here, the irradiation of zebrafish was maintained until F2 larval stage. Two dose rates were selected; the first one (0.05 mGy h-1) was close to the threshold value for the protection of aquatic ecosystems, the second one (5 mGy h-1) previously studied and known to increase morbidity (DCRL). F1 from 30d-irradiated parents were irradiated themselves (irradiated condition) or not (Recovery condition) for 131 days before reproduction. Endpoints concerned reproductive capacity (reproductive success, fecundity, egg fertilization) and larval survival in F0, F1 and F2. Multigenerational irradiation affected F1 parental reproductive capacity mainly over the first reproduction and larval survival rate. Unexpected effects on sex ratio was observed in exposed and non-exposed F1 progeny after parental irradiation (mainly at 5 mGy h-1). The worsening effects over the two generations observed here could partly explain the higher sensitivity of wild populations. Thus, this study confirm that multigenerational studies could be of interest on ecological risk assessment, in particular to determine the benchmark values.

Domaines

Ecotoxicologie
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Dates et versions

hal-03609780 , version 1 (31-03-2022)

Identifiants

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Noémie Guirandy, Beatrice Gagnaire, Virginie Camilleri, Isabelle Cavalie, Fabien Pierron, et al.. Multigenerational exposure to gamma radiation affects offspring differently over generations in Zebrafish. Aquatic Toxicology, 2022, 244, pp.106401. ⟨10.1016/j.aquatox.2022.106101⟩. ⟨hal-03609780⟩
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