The aim of this report is twice: Firstly, it proposes a general strategy for data collection inside M4D project and more generally at the level of ESPON program. The Core Database Strategy (CDS) is an attempt to propose an innovative solution against the current situation where the ESPON database is adversely affected by the accumulation of heterogeneous data that are more and more difficult to manage. The report describes the general aims of this new strategy and the expected benefits, in particular when it comes to territorial monitoring. Secondly, it presents the preliminary tests and results of this strategy in the case of regional data. We examine firstly the current list of core indicators likely to support the CDS. Then we propose methods for the estimation of missing values and building of long term time series of core indicators. Finally we demonstrate how such core indicators can be combined with accessibility measure in order to produce innovative measure of functional dynamics.