Obinutuzumab as treatment for ANCA-associated vasculitis - Archive ouverte HAL
Article Dans Une Revue Rheumatology Année : 2021

Obinutuzumab as treatment for ANCA-associated vasculitis

Résumé

Abstract Objectives Rituximab is a standard of care therapy for patients with ANCA-associated vasculitis. When rituximab is contraindicated, or in the case of refractory disease, other treatments are needed. Obinutuzumab is another anti-CD20 antibody for the treatment of haematological malignancies that may induce a deeper B cell depletion compared with rituximab. This article reviews three cases of patients with ANCA-associated vasculitis who were treated with obinutuzumab due to their history of anaphylactic reactions to rituximab. Methods Case series of three patients with ANCA-associated vasculitis treated with obinutuzumab. Results One female patient with microscopic polyangiitis and two male patients with granulomatosis with polyangiitis received obinutuzumab. The treatment was well-tolerated in all patients despite previous anaphylactic reaction to rituximab. Treatment with obinutuzumab was effective in (i) inducing disease remission, (ii) inducing total B cell depletion, and (iii) resulting in undetectable serum titres of ANCA. All three patients were re-treated with obinutuzumab for maintenance of remission. Conclusion Obinutuzumab appears to be a safe and efficacious therapy for patients with ANCA-associated vasculitis who have had refractory disease or a history of anaphylaxis to rituximab. Prospective studies comparing rituximab to obinutuzumab in ANCA-associated vasculitis patients are warranted.

Domaines

Immunologie

Dates et versions

hal-03608455 , version 1 (14-03-2022)

Identifiants

Citer

Naomi Amudala, Sara Boukhlal, Brittany Sheridan, Carol Langford, Abdallah Geara, et al.. Obinutuzumab as treatment for ANCA-associated vasculitis. Rheumatology, 2021, ⟨10.1093/rheumatology/keab916⟩. ⟨hal-03608455⟩
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