A Dynamic Model for Estimating the Interaction of ROS–PUFA–Antioxidants in Rabbit - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Antioxidants Année : 2022

A Dynamic Model for Estimating the Interaction of ROS–PUFA–Antioxidants in Rabbit

Résumé

Defining optimal nutrition in animals and humans remains a main scientific challenge. The objective of the work was to develop a dynamic model of reactive oxygen species (ROS)–polyunsaturated fatty acid (PUFA)–antioxidant homeostasis using the rabbit as a model. The problem entity was to evaluate the main metabolites generated from interactions between traits included in the conceptual model and identified by three main sub–models: (i) ROS generation, (ii) PUFA oxidation and (iii) antioxidant defence. A mathematical model (VENSIM software) that consisted of molecular stocks (INPUTs, OUTPUTs), exchange flows (intermediate OUTPUTs) and process rates was developed. The calibration was performed by using standard experimental data (Experiment 1), whereas the validation was carried out in Experiments 2 and 3 by using supra–nutritional dietary inputs (VIT E+ and PUFA+). The accuracy of the models was measured using 95% confidence intervals. Analytical OUTPUTs (ROS, PUFA, Vit E, Ascorbic acid, Iso–/NeuroProstanes, Aldehydes) were well described by the standard model. There was also good accuracy for the VIT E+ scenario, whereas some compensatory rates (Kc1–Kc4) were added to assess body compensation when high levels of dietary PUFA were administered (Experiment 3). In conclusion, the model can be very useful for predicting the effects of dietary treatments on the redox homeostasis of rabbits.
Fichier principal
Vignette du fichier
Mattioli et al antioxidants 2022,11-531.pdf (10.54 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03607550 , version 1 (14-03-2022)

Licence

Paternité

Identifiants

Citer

Simona Mattioli, Corrado Dimauro, Alberto Cesarani, Alessandro Dal Bosco, Desiree Bartolini, et al.. A Dynamic Model for Estimating the Interaction of ROS–PUFA–Antioxidants in Rabbit. Antioxidants , 2022, 11 (3), pp.531. ⟨10.3390/antiox11030531⟩. ⟨hal-03607550⟩
16 Consultations
14 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More