Since the start of industrialization, machine capabilities have increased in such a way that human control of processes has evolved from simple (with mechanization) to cognitive (with computerization), and even emotional (with semi/full automation). The processes have also evolved from simple to complicated, and now complex systems, in the emerging context of Industry 4.0. The objective of the special issue “Human and Industry 4.0” is to benefit from studies and results from current manufacturing projects to highlight clues and good practices to design intelligent manufacturing systems for Industry 4.0, then paying attention to human involvements in order to unsure what it looks like in practice and how to realize these systems, especially when it comes to maintenance and operations. This paper aims to summarize the scientific papers that contributed to the Special Issue “Human and Industry 4.0”