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              <p>INTRODUCTION – CONSTANCES is a very large “generalist” population-based cohort designed for health research and for providing public health information.MATERIAL-METHODS – The cohort is composed of a representative sample of the French population aged 18-69 years; the expected total size is 200,000 subjects. The inclusion of participants takes place in a health examination center of the insurance scheme, where they receive a medical examination and complete a questionnaire about their health, their lifestyle and occupational history. A biobank (blood and urine) is constituted. The follow-up includes an annual self-administered questionnaire, a medical examination every five years, and the linkage to the SNIIRAM (national inter-scheme health insurance information system), the CNAV (National Old-Age Insurance Fund) and CépiDc (System for Automated Coding of Causes of Death) databases. The data collected from these sources are related to health, socio-professional characteristics, care seeking, biological, physiological, physical and cognitive parameters. Quality control and validation of health events are performed. Consideration of selection effects is based on a random sample of non-participants.ADVANCEMENT – Currently (October 2016), more than 115,000 participants were included in the cohort, and about 3,000 new volunteers are included each month. More than 60 projects on various topics were positively assessed by the cohort International Scientific Council. Public-private partnerships have also been established, as planned in the context of the financing of CONSTANCES by “Investments in the future”.</p>
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              <p>Introduction-Constances est une cohorte « généraliste » de très grande taille en population destinée à la recherche en santé et à fournir des informations à visée de santé publique. Matériel-méthodes-La cohorte est composée d'un échantillon visant à la représentativité de la population française âgée de 18 à 69 ans ; l'effectif total prévu est de 200 000 sujets. L'inclusion des participants a lieu dans les Centres d'examens de santé (CES) de la Sécurité sociale, où ils bénéficient d'un examen médical et complètent un questionnaire concernant leur santé, leurs modes de vie et un historique professionnel. Une biobanque (sang et urine) est constituée. Le suivi se fait par auto-questionnaire annuel, examen médical tous les cinq ans et par appariement aux bases de données du Sniiram (Système national d'information inter-régimes de l'Assurance maladie), de la Cnav (Caisse nationale d'assurance vieillesse) et du CépiDc-Inserm (Centre d'épidémio logie sur les causes médicales de décès). Les données recueillies à ces différentes sources concernent la santé, les caractéristiques socioprofessionnelles, le recours aux soins, des paramètres biologiques, physiologiques, physiques et cognitifs. Un contrôle de qualité et une validation des événements de santé ont été mis en place. La prise en compte des effets de sélection s'appuie sur un échantillon aléatoire de non-participants. État d'avancement-Actuellement (octobre 2016), plus de 115 000 participants ont été inclus dans la cohorte et environ 3 000 nouveaux volontaires sont inclus chaque mois. Plus de 60 projets portant sur des thèmes diversifiés ont été évalués positivement par le Conseil scientifique international de la cohorte. Des partenariats publicprivé ont également été mis en place, comme cela est prévu dans le cadre du financement de Constances par les Investissements d'avenir.</p>
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