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                <title xml:lang="en">Impact of age, gender and education on cognitive performance in subjects aged from 45 to 75 years in the French Constancs Cohort</title>
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                <term xml:lang="en">Age</term>
                <term xml:lang="en">Sex</term>
                <term xml:lang="en">Education</term>
                <term xml:lang="en">Cohort</term>
                <term xml:lang="en">Cognitive performance</term>
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                <term xml:lang="fr">Sexe</term>
                <term xml:lang="fr">Fonction cognitive</term>
                <term xml:lang="fr">Performance cognitive</term>
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              <p>OBJECTIVE – The aim of our study was to quantify the importance of the effect of age, sex and education on four transversal measures of cognitive function in an elderly population age from 45 to 75. METHODS – Cognitive functions were assessed in 25,748 volunteers (45 to 75-years-old) included in the French CONSTANCES cohort between January 2012 and May 2014, using (1) the Free and Cued Selective Reminding Test (FCSRT, “immediate” and “delayed” free recall scores), (2) Verbal Fluency Tasks (semantic and phonemic), (3) the Digit Symbol Substitution Test (DSST) and (4) Trail Making Test (TMT, parts A and B). The importance of the associations was quantiﬁed using ω2 coefﬁcient representing the percentage of variation of cognitive scores which can be explained by age, sex and education level. RESULTS – Age explained 0.6% of the variation of the scores of verbal ﬂuency, this proportion reached 8.1% for the TMT-A. Sex was reported for 6.3% and 5.0% of the variation of the two scores of the FCSRT, 2.5% of those of the DSST and 0.7% of those of the phonemic ﬂuency. The level of education explained 1.8% of the variation of the TMT-A, the proportion reached 11.5% for the DSST. Finally, age, sex and education considered simulta-neously explained from 8% (for semantic ﬂuency) to 24% (for DSST) of the variations of cognitive scores. CONCLUSION – Age, sex and education are strongly associated with cognitive performance.</p>
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              <p>Objectif-L'objectif de notre étude était de quantifier l'importance de l'effet de l'âge, du sexe et de l'éducation sur la mesure transversale de quatre tests neuropsychologiques dans une population âgée de 40 à 75 ans. Méthodes-Les fonctions cognitives ont été évaluées chez 25 748 volontaires âgés de 45 à 75 ans, inclus dans la cohorte Constances entre janvier 2012 et mai 2014. Les scores des tests neuropsychologiques utilisés étaient (1) les rappels libres, immédiat et différé, du test « Rappel libre et rappel indicé à 16 items » (RLRI16), (2) les tâches de fluence verbale sémantique et phonémique, (3) le « Digit Symbol Substitution Test » (DSST), et (4) les parties A et B du « Trail Making Test » (TMT-A et B). L'importance des associations a été quantifiée à l'aide de coefficients ω 2 représentant les pourcentages de variation des scores pouvant être expliqués par l'âge, le sexe et le niveau d'éducation. Résultats-L'âge expliquait 0,6% des variations des scores de fluence verbale ; cette proportion s'élevait jusqu'à 8,1% pour le test TMT-A. Le sexe rendait compte de 6,3% et 5,0% des variations des deux scores du RL/RI16, 2,5% de celles du DSST et 0,7% de celles de la fluence phonémique. Concernant l'éducation, le niveau d'études expliquait 1,8% des variations du TMT-A et la proportion allait jusqu'à 11,5 % pour le test DSST. Au final, l'âge, le sexe et l'éducation considérés simultanément expliquaient de 8% (pour la fluence sémantique) à 24% (pour la DSST) des variations des scores cognitifs. Conclusion-L'âge, le sexe et l'éducation sont fortement associés aux performances cognitives. Objective-The aim of our study was to quantify the importance of the effect of age, sex and education on four transversal measures of cognitive function in an elderly population age from 45 to 75. Methods-Cognitive functions were assessed in 25,748 volunteers (45 to 75-years-old) included in the French CONSTANCES cohort between January 2012 and May 2014, using (1) the Free and Cued Selective Reminding Test (FCSRT, "immediate" and "delayed" free recall scores), (2) Verbal Fluency Tasks (semantic and phonemic),</p>
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