Analgesic effects of dyspnoea: “Air hunger” does not inhibit the spinal nociception reflex in humans - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Respiratory Physiology & Neurobiology Année : 2014

Analgesic effects of dyspnoea: “Air hunger” does not inhibit the spinal nociception reflex in humans

Capucine Morélot-Panzini
  • Fonction : Auteur
Julien Mayaux
  • Fonction : Auteur
Jean-Claude Willer
  • Fonction : Auteur
Thomas Similowski

Résumé

Dyspnoea has distinct sensory modalities, including air hunger and the sensation of excessive breathing "work/effort". Both have analgesic properties. In the case of work/effort, spinal mechanisms have been documented (inhibitory effect on the spinal nociceptive flexor reflex, RIII). This mechanism involves C-fibres. As C-fibres are unlikely to play a major role in air hunger, we hypothesised that inducing this type of dyspnoea would not result in RIII inhibition. Eight healthy volunteers were exposed to a hypercapnic hyperoxic gas mixture (5% CO2 and 95% O2) and asked to voluntarily fight the corresponding ventilatory reflex response by reducing tidal volume below its spontaneous level. Ventilatory variables and dyspnoea intensity (ordinal scale) were measured. Electromyography of the biceps femoris was used to record the amplitude of RIII in response to painful electrical sural nerve stimulation. Air hunger failed to inhibit the RIII reflex. We conclude that the mechanisms of air hunger induced analgesia do not include a spinal contribution and are therefore mostly central.
Fichier non déposé

Dates et versions

hal-03600630 , version 1 (07-03-2022)

Identifiants

Citer

Capucine Morélot-Panzini, Julien Mayaux, François Hug, Jean-Claude Willer, Thomas Similowski. Analgesic effects of dyspnoea: “Air hunger” does not inhibit the spinal nociception reflex in humans. Respiratory Physiology & Neurobiology, 2014, 190, pp.81-85. ⟨10.1016/j.resp.2013.09.012⟩. ⟨hal-03600630⟩
8 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More