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Journal Articles Biomaterials Year : 2006

Preparation, physical-chemical characterisation and cytocompatibility of calcium carbonate cements

Abstract

The feasibility of calcium carbonate cements involving the recrystallisation of metastable calcium carbonate varieties has been demonstrated. Calcium carbonate cement compositions presented in this paper can be prepared straightforwardly by simply mixing water (liquid phase) with two calcium carbonate phases (solid phase) which can be easily obtained by precipitation. An original cement composition was obtained by mixing amorphous calcium carbonate and vaterite with an aqueous medium. The cement set and hardened within 2 hours at 37°C in an atmosphere saturated with water and the final composition of the cement consisted mostly of aragonite. The hardened cement was microporous and showed poor mechanical properties. Cytotoxicity tests revealed excellent cytocompatibility of calcium carbonate cement compositions. Calcium carbonates with a higher solubility than the marketed calcium phosphate cements might be of interest to increase biomedical cement resorption rates and to favour its replacement by bone tissue.

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Materials
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hal-03599512 , version 1 (07-03-2022)

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Christèle Combes, Baoji Miao, Reine Bareille, Christian Rey. Preparation, physical-chemical characterisation and cytocompatibility of calcium carbonate cements. Biomaterials, 2006, 27 (9), pp.1945-1954. ⟨10.1016/j.biomaterials.2005.09.026⟩. ⟨hal-03599512⟩
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