Article Dans Une Revue Scientific Reports Année : 2021

Flexible brain dynamics underpins complex behaviours as observed in Parkinson’s disease

Rosaria Rucco
Fabio Baselice
Rosa de Micco
  • Fonction : Auteur
Alessandro Tessitore
  • Fonction : Auteur
Arjan Hillebrand
  • Fonction : Auteur
Laura Mandolesi
Michael Breakspear
  • Fonction : Auteur
Leonardo Gollo
  • Fonction : Auteur
Giuseppe Sorrentino

Résumé

Abstract Rapid reconfigurations of brain activity support efficient neuronal communication and flexible behaviour. Suboptimal brain dynamics is associated to impaired adaptability, possibly leading to functional deficiencies. We hypothesize that impaired flexibility in brain activity can lead to motor and cognitive symptoms of Parkinson’s disease (PD). To test this hypothesis, we studied the ‘functional repertoire’—the number of distinct configurations of neural activity—using source-reconstructed magnetoencephalography in PD patients and controls. We found stereotyped brain dynamics and reduced flexibility in PD. The intensity of this reduction was proportional to symptoms severity, which can be explained by beta-band hyper-synchronization. Moreover, the basal ganglia were prominently involved in the abnormal patterns of brain activity. Our findings support the hypotheses that: symptoms in PD relate to impaired brain flexibility, this impairment preferentially involves the basal ganglia, and beta-band hypersynchronization is associated with reduced brain flexibility. These findings highlight the importance of extensive functional repertoires for correct behaviour.

Domaines

Fichier principal
Vignette du fichier
41598_2021_Article_83425.pdf (1.72 Mo) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)
Licence

Dates et versions

hal-03599044 , version 1 (28-09-2023)

Licence

Identifiants

Citer

Pierpaolo Sorrentino, Rosaria Rucco, Fabio Baselice, Rosa de Micco, Alessandro Tessitore, et al.. Flexible brain dynamics underpins complex behaviours as observed in Parkinson’s disease. Scientific Reports, 2021, 11 (1), pp.4051. ⟨10.1038/s41598-021-83425-4⟩. ⟨hal-03599044⟩
85 Consultations
69 Téléchargements

Altmetric

Partager

  • More