The holy grail of pyrene-based surface ligands on the sensitivity of graphene-based field effect transistors
Vladyslav Mishyn
(1)
,
Adrien Hugo
(1)
,
Teresa Rodrigues
(2)
,
Patrik Aspermair
(2)
,
Henri Happy
(1, 3)
,
Leonel Marques
,
Charlotte Hurot
,
Riadh Othmen
,
Vincent Bouchiat
,
Rabah Boukherroub
(1, 4)
,
Wolfgang Knoll
(2)
,
Sabine Szunerits
(1, 4)
Vladyslav Mishyn
- Fonction : Auteur
- PersonId : 1334952
- IdHAL : vladyslav-mishyn
Patrik Aspermair
- Fonction : Auteur
- PersonId : 804952
- ORCID : 0000-0003-1671-1328
- IdRef : 253505658
Henri Happy
- Fonction : Auteur
- PersonId : 748086
- IdHAL : henri-happy
- ORCID : 0000-0003-2065-8080
- IdRef : 103891455
Leonel Marques
- Fonction : Auteur
Charlotte Hurot
- Fonction : Auteur
- PersonId : 1151930
- ORCID : 0000-0002-8753-1458
- IdRef : 256371059
Riadh Othmen
- Fonction : Auteur
Vincent Bouchiat
- Fonction : Auteur
Rabah Boukherroub
- Fonction : Auteur
- PersonId : 177969
- IdHAL : rabah-boukherroub
- ORCID : 0000-0002-9795-9888
- IdRef : 139279474
Wolfgang Knoll
- Fonction : Auteur
- PersonId : 776843
- ORCID : 0000-0003-1543-4090
- IdRef : 113981597
Sabine Szunerits
- Fonction : Auteur
- PersonId : 21321
- IdHAL : sabine-szunerits
- ORCID : 0000-0002-1567-4943
- IdRef : 097506362
Résumé
Graphene has received intensive research interest due to its remarkable charge mobility, and the efforts in the use of graphene-based field effect transistors (GFETs) for the sensing of biological biomarkers is on the rise. Because of the high non-specific protein adsorption on graphene, well-defined surface modification strategies have to be implemented to benefit from the excellent electronic transfer characteristics of GFET devices for specific detection of biomarkers. Surprisingly, while pyrene-based ligands are the most widely used graphene surface anchors for sensing-related applications, no systematic investigation on the reaction conditions employed and the influence of pyrene functionalities has been reported so far. As this is one of the essential steps for efficient receptor integration and sensitive sensing, by using GFET-based analysis of cardiac troponin I (cTnI) as the model compound we will show that an optimized pyrene–maleimide ligand incubation time on graphene of 2 h gives the best sensing performance. This study not only will be a guideline for researchers interested in GFET biosensors but also will hopefully allow industrial GFET development in a faster path.
Format du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Résumé |
en
Graphene has received intensive research interest due to its remarkable charge mobility, and the efforts in the use of graphene-based field effect transistors (GFETs) for the sensing of biological biomarkers is on the rise. Because of the high non-specific protein adsorption on graphene, well-defined surface modification strategies have to be implemented to benefit from the excellent electronic transfer characteristics of GFET devices for specific detection of biomarkers. Surprisingly, while pyrene-based ligands are the most widely used graphene surface anchors for sensing-related applications, no systematic investigation on the reaction conditions employed and the influence of pyrene functionalities has been reported so far. As this is one of the essential steps for efficient receptor integration and sensitive sensing, by using GFET-based analysis of cardiac troponin I (cTnI) as the model compound we will show that an optimized pyrene–maleimide ligand incubation time on graphene of 2 h gives the best sensing performance. This study not only will be a guideline for researchers interested in GFET biosensors but also will hopefully allow industrial GFET development in a faster path.
|
Titre |
en
The holy grail of pyrene-based surface ligands on the sensitivity of graphene-based field effect transistors
|
Auteur(s) |
Vladyslav Mishyn
1
, Adrien Hugo
1
, Teresa Rodrigues
2
, Patrik Aspermair
2
, Henri Happy
1, 3
, Leonel Marques
, Charlotte Hurot
, Riadh Othmen
, Vincent Bouchiat
, Rabah Boukherroub
1, 4
, Wolfgang Knoll
2
, Sabine Szunerits
1, 4
1
IEMN -
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520
( 1066983 )
- [Univ. Lille, CNRS, Centrale Lille Institut, Junia, Univ. Polytechnique Hauts-de-France] ––
Laboratoire Central – Cité Scientifique – Avenue Poincaré – CS 60069 – 59652 VILLENEUVE D’ASCQ CEDEX
- France
2
AIT -
Austrian Institute of Technology [Vienna]
( 196396 )
- Donau-City-Straße 1
1220 Vienna
- Autriche
3
CARBON - IEMN -
Carbon - IEMN
( 1067376 )
- Groupe Carbon - IEMN UMR8520
- France
4
NBI - IEMN -
NanoBioInterfaces - IEMN
( 1067477 )
- Groupe NBI - CCHB IRCICA - 50 Avenue Halley - 59650 Villeneuve d'Ascq
- France
|
Date de publication électronique |
2022-01-05
|
Volume |
1
|
Page/Identifiant |
235-244
|
Date de publication |
2022-03-01
|
Numéro |
2
|
Licence |
Paternité
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Projet(s) ANR |
|
Financement |
|
Référence interne |
|
Collaboration/Projet |
|
Domaine(s) |
|
DOI | 10.1039/d1sd00036e |
Origine :
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