Identification of Molecular Fragments in Equilibrium with Polysiloxane Ultrasmall Nanoparticles
Identification de fragments moléculaires en équilibre avec des nanoparticules ultrasiloxanes de polysiloxane
Résumé
During recent decades, ultrasmall inorganic nanoparticles have attracted considerable interest due to their favorable biodistribution, pharmacokinetics and theranostic properties. In particular, AGuIX nanoparticles made of polysiloxane and gadolinium chelates were successfully translated to the clinics. In an aqueous medium, these nanoparticles are in dynamic equilibrium with polysiloxane fragments due to the hydrolysis of Si–O–Si bonds. Thanks to high-performance liquid chromatography coupled with electrospray ionization mass spectrometry, all these fragments were separated and identified.
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