Antibiotic resistance is a rapidly growing threat to global public health. This study looked at the potential of a polyphenolic rich extract from maple syrup (PRMSE) to potentiate the effects of common antibiotics in vivo, which could lessen the need for antibiotic usage. Results indicated that PRMSE and ciprofloxacin combination therapy displayed synergy against P. aeruginosa in and murine infection models at clinically relevant doses, suggesting that PRMSE may have potential as an antibiotic adjuvant for the treatment of different types of bacterial infections