The purpose of this research work is to propose a territorial resilience assessment methodology, based on Multi-criteria decision-making (MCDM) methods. Mobilizing a multidisciplinary research approach that encourages interactions between the theoretical concepts and the field practices, we propose a framework of evaluation criteria illustrating the phenomenon of territorial resilience and enabling to observe how it manifests. This methodology is currently implemented at the scale of the French Grand Est-Lorraine Region through a specific case study: the DHDA project (supported by the French government through its program "Plan d'Investissement d'Avenir - Territoire d'Innovation". Through this case study, we aim to highlight a way to pilot territorial resilience at a local scale, by observing, analyzing and understanding field practices in real context.