A Journey through Time on the Discovery of Cell Cycle Regulation - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Cells Année : 2022

A Journey through Time on the Discovery of Cell Cycle Regulation

Résumé

All living organisms on Earth are made up of cells, which are the functional unit of life. Eukaryotic organisms can consist of a single cell (unicellular) or a group of either identical or different cells (multicellular). Biologists have always been fascinated by how a single cell, such as an egg, can give rise to an entire organism, such as the human body, composed of billions of cells, including hundreds of different cell types. This is made possible by cell division, whereby a single cell divides to form two cells. During a symmetric cell division, a mother cell produces two daughter cells, while an asymmetric cell division results in a mother and a daughter cell that have different fates (different morphologies, cellular compositions, replicative potentials, and/or capacities to differentiate). In biology, the cell cycle refers to the sequence of events that a cell must go through in order to divide. These events, which always occur in the same order, define the different stages of the cell cycle: G1, S, G2, and M. What is fascinating about the cell cycle is its universality, and the main reason for this is that the genetic information of the cell is encoded by exactly the same molecular entity with exactly the same structure: the DNA double helix. Since both daughter cells always inherit their genetic information from their parent cell, the underlying fundamentals of the cell cycle—DNA replication and chromosome segregation—are shared by all organisms. This review goes back in time to provide a historical summary of the main discoveries that led to the current understanding of how cells divide and how cell division is regulated to remain highly reproducible.
Fichier principal
Vignette du fichier
cells-11-00704.pdf (2.34 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03587322 , version 1 (02-06-2022)

Licence

Paternité

Identifiants

Citer

Rustem Uzbekov, Claude Prigent. A Journey through Time on the Discovery of Cell Cycle Regulation. Cells, 2022, 11 (4), pp.704. ⟨10.3390/cells11040704⟩. ⟨hal-03587322⟩
46 Consultations
152 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More