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Article Dans Une Revue Langmuir Année : 2022

Fusion Dynamics of Hybrid Cell–Microparticle Aggregates: A Jelly Pearl Model

Résumé

We study the fusion of homogeneous cell aggregates and of hybrid aggregates combining cells and microparticles. In all cases, we find that the contact area does not vary linearly over time, as observed for liquid drops, but rather it follows a power law in t2/3. This result is interpreted by generalizing the fusion model of soft viscoelastic solid balls to viscoelastic liquid balls, akin to jelly pearls. We also explore the asymmetric fusion between a homogeneous aggregate and a hybrid aggregate. This latter experiment allows the determination of the self-diffusion coefficient of the cells in a tissue by following the spatial distribution of internalized particles in the cells.
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Dates et versions

hal-03585396 , version 1 (23-02-2022)

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Grégory Beaune, Laura Sinkkonen, David Gonzalez-Rodriguez, Jaako V. I. Timonen, Françoise Brochard-Wyart. Fusion Dynamics of Hybrid Cell–Microparticle Aggregates: A Jelly Pearl Model. Langmuir, In press, pp.acs.langmuir.1c02949. ⟨10.1021/acs.langmuir.1c02949⟩. ⟨hal-03585396⟩
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