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Article Dans Une Revue Trends in Pharmacological Sciences Année : 1995

An evolutionary view of drug-receptor interaction: the bioamine receptor family

Résumé

The large molecular diversity of receptors and their subtypes means that the pharmacologist is faced with many puzzling characterization questions. First, the molecular diversity of the receptors is deciphered only in part by a pharmacological approach, which precludes a satisfactory receptor classification based solely on pharmacological characteristics. Second, the physiological counterpart of the numerous subtypes of receptors specifically activated by single endogenous ligands remains unclear. Here, Philippe Vernier and colleagues use the example of the bioamine G protein-coupled receptors to show that many of the apparent inconsistencies that emerge from pharmacological and molecular characterizations of receptors can be better understood if the evolutionary history of the receptors is taken into account.

Dates et versions

hal-03577196 , version 1 (16-02-2022)

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Philippe Vernier, Bruno Cardinaud, Olivier Valdenaire, Hervé Philippe, Jean-Didier Vincent. An evolutionary view of drug-receptor interaction: the bioamine receptor family. Trends in Pharmacological Sciences, 1995, 16 (11), pp.375-381. ⟨10.1016/s0165-6147(00)89078-1⟩. ⟨hal-03577196⟩

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