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Chapitre D'ouvrage Année : 1990

Analysis of Glial Scarring in the Mammalian CNS with a GFAP cDNA Probe

Résumé

Reactive gliosis, leading to the formation of glial scar, is the response of astrocytes to CNS injury. It is an ubiquitous reaction observed in a large number of pathological conditions, such as mechanical and chemical lesions, as well as degenerative processes (Fulcrand and Privat, 1977; Eng and De Armond, 1982). This reaction is twofold, being characterized by an astrocyte multiplication (hyperplasia) as well as an hypertrophy of the perikarya and processes (Hain et al., 1960; Nathaniel and Nathaniel, 1981). The main intracellular event is an increase of the number of gliafilaments, paralleled by a raise in GFAP immunoreactivity.
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hal-03576648 , version 1 (16-02-2022)

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Pierre Rataboul, Philippe Vernier, Alain Privat. Analysis of Glial Scarring in the Mammalian CNS with a GFAP cDNA Probe. Molecular Aspects of Development and Aging of the Nervous System, 265, Springer US, pp.23-40, 1990, Advances in Experimental Medicine and Biology, ⟨10.1007/978-1-4757-5876-4_3⟩. ⟨hal-03576648⟩

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