Substance P-immunoreactivity in the dorsal medial region of the medulla in the cat: effects of nodosectomy. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Chemical Neuroanatomy Année : 1989

Substance P-immunoreactivity in the dorsal medial region of the medulla in the cat: effects of nodosectomy.

J Lanoir
  • Fonction : Auteur
J Puizillout
  • Fonction : Auteur

Résumé

The distribution of substance P in the vagal system of the cat was studied by immunohistochemistry. Substance P-immunoreactive cell bodies and fibres were observed in the nodose ganglion. Numerous substance P-immunoreactive terminals and fibres were localized in their bulbar projection area, i.e. throughout the caudo-rostral extent of the nucleus of the solitary tract. Four subnuclei, among the nine forming the nucleus of the solitary tract, were strongly labelled: interstitial, gelatinosus, dorsal and commissural. The dorsal motor nucleus of the vagus nerve also exhibited numerous substance P-immunoreactive terminals, sometimes closely apposed on the somata of preganglionic neurons. To determine the substance P component of the vagal afferent system a nodose ganglion was removed on one side. The ablation triggered ipsilaterally a large decrease of substance P immunoreactivity in the four subnuclei strongly labelled on normal cats. These results suggest the involvement of substance P-containing vagal fibres in integrative processes of the central regulation of cardiovascular, digestive and respiratory systems, viscerotopically organized throughout these four subnuclei. The nodose ablation also resulted in a decrease of substance P immunoreactivity in the ipsilateral dorsal motor nucleus of the vagus nerve, suggesting monosynaptic vago-vagal interactions.
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Dates et versions

hal-03576606 , version 1 (16-02-2022)

Identifiants

  • HAL Id : hal-03576606 , version 1
  • PUBMED : 2481465

Citer

A Baude, J Lanoir, Philippe Vernier, J Puizillout. Substance P-immunoreactivity in the dorsal medial region of the medulla in the cat: effects of nodosectomy.. Journal of Chemical Neuroanatomy, 1989, 2 (2), pp.67-81. ⟨hal-03576606⟩

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