The replication crisis in psychology has led to question popular phenomena such as ego depletion, which has been criticized after studies failed to replicate. Here, we describe limitations in the literature that contributed to these failures and suggest how they may be addressed. At the theoretical level, the literature focuses on two out of at least eight identified auxiliary hypotheses. Thus, the majority of the hypotheses related to the three core assumptions of the ego-depletion theory have been overlooked, thereby preventing the rejection of the theory as a whole. At the experimental level, we argue that the low replicability of ego-depletion studies could be explained by the absence of a comprehensive, integrative, and falsifiable definition of self-control, which is central to the concept of ego depletion; by an unclear or absent distinction between ego depletion and mental fatigue, two phenomena that rely on different processes; and by the low validity of the tasks used to induce ego depletion. Finally, we make conceptual and methodological suggestions for a more rigorous investigation of ego depletion, discuss the necessity to take into account its dynamic and multicomponent nature, and suggest using the term self-control fatigue instead.