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Article Dans Une Revue Clinical Immunology Année : 2022

Long non-coding RNA Xist contribution in systemic lupus erythematosus and rheumatoid arthritis

Résumé

Growing evidence points towards the role of the long non-coding (lnc)-RNA Xist expressed in female cells as a predominant key actor for the sex bias observed in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Indeed, in female cells, lnc-Xist controls transcription directly by spreading across the inactivated X chromosome (Xi) and indirectly by sequestring miRNAs as a sponge. The inactivation process at Xi is altered in lymphocytes from SLE women and associated with important variations in ribonucleoproteins (RNP) associated with lnc-Xist. In fibroblast-like synoviocytes (FLS) and osteoclasts from RA women, proinflammatory and proliferative pathways are upregulated due to the sequestration effect exerted by lnc-Xist overexpression on miRNAs. The key role played by lnc-Xist in SLE and RA is further supported by it's knock down that recapitulates the SLE B cell extrafollicular profile and controls RA associated FLS proinflammatory cytokine production and proliferation.

Dates et versions

hal-04019875 , version 1 (08-03-2023)

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Chloé Bost, Marina Arleevskaya, Wesley Brooks, Samuel Plaza, Jean-Charles Guery, et al.. Long non-coding RNA Xist contribution in systemic lupus erythematosus and rheumatoid arthritis. Clinical Immunology, 2022, 236, pp.108937. ⟨10.1016/j.clim.2022.108937⟩. ⟨hal-04019875⟩
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