Is the Alpha Variant of SARS-CoV-2 Associated with a Higher Viral Load Than the Historical Strain in Saliva Samples in Patients with Mild to Moderate Symptoms? - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Life Année : 2021

Is the Alpha Variant of SARS-CoV-2 Associated with a Higher Viral Load Than the Historical Strain in Saliva Samples in Patients with Mild to Moderate Symptoms?

Résumé

During the COVID-19 pandemic, several generic variants emerged, including the Alpha variant, with increased transmissibility compared to historical strains. We aimed to compare the evolution of the viral load between patients infected with the Alpha variant and those infected with the historical SARS‐CoV‐2 strains, while taking into account the time interval between the onset of symptoms and samples. We used data collected from patients with an acute respiratory infection (mild to moderate symptoms) and seen in consultation in primary care, included in a prospective longitudinal study, COVID‐A. Patients performed four salivary samples during the follow‐up. All patients who had at least one of the saliva samples test positive for SARS‐CoV‐2 were included in the analysis. Overall, 118 patients were included: 89 infected by the historical strain and 29 infected by the Alpha variant. Even though we tended to observe a higher viral load in the Alpha variant group, we found no significant difference in the evolution of the viral load in saliva samples between patients infected with the Alpha variant of the SARS‐CoV‐2 and those infected by historical strains when controlling for the time interval between the onset of symptoms and sampling.
Fichier principal
Vignette du fichier
life-12-00163-v2.pdf (1.03 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-03554153 , version 1 (07-03-2022)

Licence

Paternité

Identifiants

Citer

Camille Bonnet, Shirley Masse, Hayat Benamar, Ana Maria Vilcu, Morgane Swital, et al.. Is the Alpha Variant of SARS-CoV-2 Associated with a Higher Viral Load Than the Historical Strain in Saliva Samples in Patients with Mild to Moderate Symptoms?. Life, 2021, 12 (2), pp.163. ⟨10.3390/life12020163⟩. ⟨hal-03554153⟩
72 Consultations
33 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More